In:
Journal of the European Academy of Dermatology and Venereology, Wiley, Vol. 33, No. 1 ( 2019-01), p. 198-203
Abstract:
Sarcoidosis, characterized by epithelioid granulomas, is considered to be caused by a complex interplay between genetics and environmental agents. It has been hypothesized that exogenous inorganic particles as crystalline silica could be a causal or adjuvant agent in sarcoidosis onset. Objectives To investigate the location, frequency and physicochemical characteristics of foreign materials and mineral tissue deposits in the granulomatous area of cutaneous sarcoidosis. Methods Skin biopsies ( n = 14) from patients diagnosed with cutaneous sarcoidosis (mean age 43 years; 11 patients with extracutaneous involvement) were investigated using polarized light examination ( PLE ), μFourier Transform Infra‐Red (μ FT ‐ IR ) spectroscopy and Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X‐ray Spectroscopy ( FE ‐ SEM / EDX ). Results Combined PLE , μ FT ‐ IR , FE ‐ SEM / EDX analysis allowed to characterize mineral deposits in 7/14 biopsies (50%). It identified crystalline silica (SiO 2 ) inside granulomas in three biopsies and calcite (Ca CO 3 ) at their periphery in 4. Conclusion This study emphasizes the need of using combined methods for assessment of mineral deposits in granulomatous diseases. According to the location and characteristics of deposits, we can hypothesize that SiO 2 particles contribute to the granuloma formation, whereas Ca CO 3 deposits are related to the granuloma biology. However, the significance of the association between SiO 2 deposits and sarcoidosis is still disputed.
Type of Medium:
Online Resource
ISSN:
0926-9959
,
1468-3083
DOI:
10.1111/jdv.2019.33.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2022088-1
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