In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2021-11-4), p. e0258760-
Abstract:
Ali-M3, an artificial intelligence program, analyzes chest computed tomography (CT) and detects the likelihood of coronavirus disease (COVID-19) based on scores ranging from 0 to 1. However, Ali-M3 has not been externally validated. Our aim was to evaluate the accuracy of Ali-M3 for detecting COVID-19 and discuss its clinical value. We evaluated the external validity of Ali-M3 using sequential Japanese sampling data. In this retrospective cohort study, COVID-19 infection probabilities for 617 symptomatic patients were determined using Ali-M3. In 11 Japanese tertiary care facilities, these patients underwent reverse transcription-polymerase chain reaction (RT-PCR) testing. They also underwent chest CT to confirm a diagnosis of COVID-19. Of the 617 patients, 289 (46.8%) were RT-PCR-positive. The area under the curve (AUC) of Ali-M3 for predicting a COVID-19 diagnosis was 0.797 (95% confidence interval: 0.762‒0.833) and the goodness-of-fit was P = 0.156. With a cut-off probability of a diagnosis of COVID-19 by Ali-M3 set at 0.5, the sensitivity and specificity were 80.6% and 68.3%, respectively. A cut-off of 0.2 yielded a sensitivity and specificity of 89.2% and 43.2%, respectively. Among the 223 patients who required oxygen, the AUC was 0.825. Sensitivity at a cut-off of 0.5% and 0.2% was 88.7% and 97.9%, respectively. Although the sensitivity was lower when the days from symptom onset were fewer, the sensitivity increased for both cut-off values after 5 days. We evaluated Ali-M3 using external validation with symptomatic patient data from Japanese tertiary care facilities. As Ali-M3 showed sufficient sensitivity performance, despite a lower specificity performance, Ali-M3 could be useful in excluding a diagnosis of COVID-19.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0258760
DOI:
10.1371/journal.pone.0258760.g001
DOI:
10.1371/journal.pone.0258760.g002
DOI:
10.1371/journal.pone.0258760.g003
DOI:
10.1371/journal.pone.0258760.g004
DOI:
10.1371/journal.pone.0258760.g005
DOI:
10.1371/journal.pone.0258760.t001
DOI:
10.1371/journal.pone.0258760.t002
DOI:
10.1371/journal.pone.0258760.s001
DOI:
10.1371/journal.pone.0258760.s002
DOI:
10.1371/journal.pone.0258760.s003
DOI:
10.1371/journal.pone.0258760.s004
DOI:
10.1371/journal.pone.0258760.s005
DOI:
10.1371/journal.pone.0258760.s006
DOI:
10.1371/journal.pone.0258760.s007
DOI:
10.1371/journal.pone.0258760.s008
DOI:
10.1371/journal.pone.0258760.s009
DOI:
10.1371/journal.pone.0258760.r001
DOI:
10.1371/journal.pone.0258760.r002
DOI:
10.1371/journal.pone.0258760.r003
DOI:
10.1371/journal.pone.0258760.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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