In:
FEBS Letters, Wiley, Vol. 263, No. 2 ( 1990-04-24), p. 279-280
Abstract:
A C‐terminal fragment of rat pancreastatin, a 26 residue peptide amide and a fragment without a C‐terminal amide were synthesized by Fmoc‐based solid phase methods and their biological activities were compared. The rat C‐terminal fragment inhibited pancreatic exocrine secretions produced by the intravenous injection of 2‐deoxy‐D‐glucose (a central vagal nerve stimulation), whereas the fragment without a C‐terminal amide showed no effect on pancreas. These results indicate that the C‐terminal amide of this peptide is necessary to reveal its biological activity.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(90)81392-2
Language:
English
Publisher:
Wiley
Publication Date:
1990
detail.hit.zdb_id:
1460391-3
SSG:
12
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