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  • 1
    Online Resource
    Online Resource
    SASPR Edu International Pvt. Ltd ; 2023
    In:  Saudi Journal of Nursing and Health Care Vol. 6, No. 06 ( 2023-06-28), p. 184-193
    In: Saudi Journal of Nursing and Health Care, SASPR Edu International Pvt. Ltd, Vol. 6, No. 06 ( 2023-06-28), p. 184-193
    Abstract: Background: The hospital setting itself can be a cause of both hope and distress to the ill children and their families. Prolonged hospitalization and advance medical procedures and care can lead to anxiety or depression. Aim of the Study: To assess reactive anxiety and depression level among hospitalized children before and after application of art therapy intervention at pediatric ward. Material & Method: A quantitative quasi-experimental, cross sectional design. The study conducted in the medical/surgical inpatient wards at in Tabuk City- King Salman Military Hospital. It was consecutive sample, the sample size was 30 child. The researcher used a tool to assess level of reactive anxiety and depression of hospitalized children. Results: The study results showed levels of HADS Anxiety for children before test and after, its reported that (23.33%) of children tested in the hospitals their anxiety level is border line pretest and (0%) on the same level after posttest. levels of HADS depression for children before test and after, its reported that (63.33%) of children tested in the hospitals their depression level is border line pretest and deceased to (13.33%) on the posttest. DAP test showed decrease in the anxiety and depression indexes in the posttest compared to the pretest. ANOVA indicated a significant time effect pre and posttest. Thus, there is a significant evidence that there was a change is art therapy.
    Type of Medium: Online Resource
    ISSN: 2616-7921 , 2616-6186
    Language: Unknown
    Publisher: SASPR Edu International Pvt. Ltd
    Publication Date: 2023
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  • 2
    In: BMJ Case Reports, BMJ, Vol. 12, No. 7 ( 2019-07), p. e227299-
    Abstract: Oral anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) have shown significant benefit in the management of ALK-rearranged non-small cell lung cancer (NSCLC). However, almost all patients will experience disease progression after front-line ALK-TKIs such as crizotinib. Treatment with third generation ALK-TKI lorlatinib can have a significant clinical impact following disease progression, even in patients with a very poor performance status. Here, we review two clinical cases with metastatic ALK-rearranged NSCLC who had pulmonary disease control with first-generation ALK inhibitor. However, disease progressed rapidly in the central nervous system with severe neurological symptoms. Treatment with lorlatinib, a third-generation ALK-TKI, led to a rapid radiological and clinical cerebral response in both patients. Lorlatinib can overcome ALK resistance to crizotinib, and the presented cases suggest a potential role for lorlatinib in patients with rapidly progressive cerebral and leptomeningeal metastases.
    Type of Medium: Online Resource
    ISSN: 1757-790X
    Language: English
    Publisher: BMJ
    Publication Date: 2019
    detail.hit.zdb_id: 2467301-8
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