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Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

Bretagne, Stéphane ; Sitbon, Karine ; Desnos-Ollivier, Marie ; [et al.]

American Society for Microbiology ; 2022

In: mBio Vol. 13, No. 3 ( 2022-06-28)

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In: mBio, American Society for Microbiology, Vol. 13, No. 3 ( 2022-06-28)

Abstract: The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% ( P 〈 0.0001). Yeast fungemia ( n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia ( n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P 〈 0.0001). Invasive aspergillosis ( n = 1,661) and mucormycosis ( n = 314) were diagnosed mostly in hematology ( 〉 60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools. IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.

Type of Medium: Online Resource

ISSN: 2150-7511

URL: Article

DOI: 10.1128/mbio.00920-22

Language: English

Publisher: American Society for Microbiology

Publication Date: 2022

detail.hit.zdb_id: 2557172-2

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Leishmaniasis epidemiology in endemic areas of metropolitan France and its overseas territories from 1998 to 2020

Pasquier, Grégoire ; Demar, Magalie ; Lami, Patrick ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Neglected Tropical Diseases Vol. 16, No. 10 ( 2022-10-7), p. e0010745-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 10 ( 2022-10-7), p. e0010745-

Abstract: In France, leishmaniasis is endemic in the Mediterranean region, in French Guiana and to a lesser extent, in the French West Indies. This study wanted to provide an updated picture of leishmaniasis epidemiology in metropolitan France and in its overseas territories. Methodology/Principal findings Leishmaniasis cases were collected by passive notification to the French National Reference Centre for Leishmaniases (NRCL) in Montpellier from 1998 to 2020 and at the associated Centre in Cayenne (French Guiana) from 2003 to 2020. In metropolitan France, 517 autochthonous leishmaniasis cases, mostly visceral forms due to Leishmania infantum (79%), and 1725 imported cases (French Guiana excluded), mainly cutaneous leishmaniasis from Maghreb, were recorded. A slight decrease of autochthonous cases was observed during the survey period, from 0.48 cases/100,000 inhabitants per year in 1999 (highest value) to 0.1 cases/100,000 inhabitants per year in 2017 (lowest value). Conversely, imported cases increased over time (from 59.7 in the 2000s to 94.5 in the 2010s). In French Guiana, 4126 cutaneous and mucocutaneous leishmaniasis cases were reported from 2003 to 2020. The mean incidence was 103.3 cases per 100,000 inhabitants/year but varied in function of the year (from 198 in 2004 to 54 in 2006). In Guadeloupe and Martinique (French West Indies), only sporadic cases were reported. Conclusions/Significance Because of concerns about disease expansion and outbreaks in other Southern Europe countries, and leishmaniasis monitoring by the NRCL should be continued and associated with a more active surveillance.

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0010745

DOI: 10.1371/journal.pntd.0010745.g001

DOI: 10.1371/journal.pntd.0010745.g002

DOI: 10.1371/journal.pntd.0010745.g003

DOI: 10.1371/journal.pntd.0010745.g004

DOI: 10.1371/journal.pntd.0010745.g005

DOI: 10.1371/journal.pntd.0010745.s001

DOI: 10.1371/journal.pntd.0010745.s002

DOI: 10.1371/journal.pntd.0010745.s003

DOI: 10.1371/journal.pntd.0010745.s004

DOI: 10.1371/journal.pntd.0010745.s005

DOI: 10.1371/journal.pntd.0010745.s006

DOI: 10.1371/journal.pntd.0010745.s007

DOI: 10.1371/journal.pntd.0010745.r001

DOI: 10.1371/journal.pntd.0010745.r002

DOI: 10.1371/journal.pntd.0010745.r003

DOI: 10.1371/journal.pntd.0010745.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2429704-5

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Traitement des leishmanioses en France : proposition d’un référentiel consensuel

Buffet, Pierre A. ; Rosenthal, Éric ; Gangneux, Jean-Pierre ; [et al.]

Elsevier BV ; 2011

In: La Presse Médicale Vol. 40, No. 2 ( 2011-02), p. 173-184

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In: La Presse Médicale, Elsevier BV, Vol. 40, No. 2 ( 2011-02), p. 173-184

Type of Medium: Online Resource

ISSN: 0755-4982

URL: Article

DOI: 10.1016/j.lpm.2010.09.023

RVK:

XA 10000

Language: French

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2655417-3

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Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005–2006)

Leroy, Olivier ; Gangneux, Jean-Pierre ; Montravers, Philippe ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2009

In: Critical Care Medicine Vol. 37, No. 5 ( 2009-05), p. 1612-1618

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In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 37, No. 5 ( 2009-05), p. 1612-1618

Type of Medium: Online Resource

ISSN: 0090-3493

URL: Article

DOI: 10.1097/CCM.0b013e31819efac0

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2009

detail.hit.zdb_id: 2034247-0

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Comments on Leishmania major in Gorilla Feces

Bastien, Patrick ; Volf, Petr ; Depaquit, Jérôme ; [et al.]

Oxford University Press (OUP) ; 2015

In: Journal of Infectious Diseases Vol. 212, No. 3 ( 2015-08-01), p. 505-506

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In: Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 212, No. 3 ( 2015-08-01), p. 505-506

Type of Medium: Online Resource

ISSN: 0022-1899 , 1537-6613

URL: Article

DOI: 10.1093/infdis/jiv129

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2015

detail.hit.zdb_id: 1473843-0

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Virulence of Leishmania infantum Is Expressed as a Clonal and Dominant Phenotype in Experimental Infections

Garin, Yves Jean-François ; Kaufmann, S. H. E. ; Sulahian, Annie ; [et al.]

American Society for Microbiology ; 2001

In: Infection and Immunity Vol. 69, No. 12 ( 2001-12), p. 7365-7373

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In: Infection and Immunity, American Society for Microbiology, Vol. 69, No. 12 ( 2001-12), p. 7365-7373

Abstract: Human Leishmania infantum infection results in a spectrum of clinical expressions ranging from cutaneous to either asymptomatic or fatal visceral disease. In this context, characterization of parasite virulence appears to be relevant as a biological marker of intrinsic parasitic factors that can affect the pathology of leishmaniasis. Since parasite populations in naturally infected hosts are likely to be composed of multiclonal associations, we first explored the biodiversity of parasite virulence at the intrastrain level in vitro and in vivo by using 11 clones isolated from three strains previously known to express different virulence phenotypes in mice. Subsequently, we studied the course of infection in mice inoculated simultaneously or successively with strains or clones showing various virulence phenotypes. Analysis of in vitro growth characteristics showed no differences among clones from the different parental strains. By contrast, in vivo experiments evidenced a marked intrastrain heterogeneity of virulence to mice. One out of five clones obtained from a virulent strain showed a typical virulence phenotype, while the remaining four clones had low-virulence profiles, as did the six clones isolated from two low-virulence strains. In mixed multiclonal infections, the virulence phenotype was expressed as a dominant character over the associated low-virulence clones. After a challenge with either a homologous or a heterologous strain or clone, virulence phenotypes were conserved and expressed as in naive mice independently from the preexisting population. These results strongly suggest that parasite virulence in L. infantum visceral leishmaniasis is clonal and dominant in nature.

Type of Medium: Online Resource

ISSN: 0019-9567 , 1098-5522

URL: Article

DOI: 10.1128/IAI.69.12.7365-7373.2001

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2001

detail.hit.zdb_id: 1483247-1

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The advantages of nanomedicine in the treatment of visceral leishmaniasis: between sound arguments and wishful thinking

Matha, Kevin ; Calvignac, Brice ; Gangneux, Jean-Pierre ; [et al.]

Informa UK Limited ; 2021

In: Expert Opinion on Drug Delivery Vol. 18, No. 4 ( 2021-04-03), p. 471-487

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In: Expert Opinion on Drug Delivery, Informa UK Limited, Vol. 18, No. 4 ( 2021-04-03), p. 471-487

Type of Medium: Online Resource

ISSN: 1742-5247 , 1744-7593

URL: Article

DOI: 10.1080/17425247.2021.1853701

Language: English

Publisher: Informa UK Limited

Publication Date: 2021

detail.hit.zdb_id: 2232223-1

SSG: 15,3

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Experimental Pathogenicity of a Presumed Monoxenous Trypanosomatid Isolated from Humans in a Murine Model

GARIN, YVES J. F. ; SULAHIAN, ANNIE ; MÉNECEUR, PASCALE ; [et al.]

Wiley ; 2001

In: Journal of Eukaryotic Microbiology Vol. 48, No. 2 ( 2001-03), p. 170-176

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In: Journal of Eukaryotic Microbiology, Wiley, Vol. 48, No. 2 ( 2001-03), p. 170-176

Abstract: ABSTRACT. Two strains of a presumed lower trypanosomatid isolated from immunocompetent and HIV‐infected humans in French West Indies were investigated in vitro and in vivo in a murine experimental model. The ability of parasites to grow in vitro in bone marrow‐derived macrophages and their virulence in vivo were assessed. For in vivo infection, two groups of BALB/c mice were inoculated either by the subcutaneous or intravenous route with 10 7 promastigotes at day 0. Infection was monitored by measuring parasite load in liver, spleen, foot pad, popliteal, and mesenteric lymph nodes and brain from day 7 to day 150 post‐infection using a microtitration technique. Parasites multiplied in mouse macrophages in vitro. In vivo, both strains proved infective to mice and capable of visceralization and dissemination in the popliteal and mesenteric lymph nodes, liver, spleen, and even brain. Both strains elicited a strong humoral response against trypanosomatid antigen in mice, which cross‐reacted with Leishmania antigen. Contrasting with the straightforward dissemination of parasites, the infection was strikingly well tolerated by the murine host with no clinical signs and minimal tissue changes around parasitized macrophage infiltrates.

Type of Medium: Online Resource

ISSN: 1066-5234 , 1550-7408

URL: Issue

URL: Article

DOI: 10.1111/jeu.2001.48.issue-2

DOI: 10.1111/j.1550-7408.2001.tb00299.x

RVK:

WA 15000

Language: English

Publisher: Wiley

Publication Date: 2001

detail.hit.zdb_id: 2126326-7

SSG: 12

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Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

Gangneux, Jean-Pierre ; Dannaoui, Eric ; Fekkar, Arnaud ; [et al.]

Elsevier BV ; 2022

In: The Lancet Respiratory Medicine Vol. 10, No. 2 ( 2022-02), p. 180-190

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In: The Lancet Respiratory Medicine, Elsevier BV, Vol. 10, No. 2 ( 2022-02), p. 180-190

Type of Medium: Online Resource

ISSN: 2213-2600

URL: Article

DOI: 10.1016/S2213-2600(21)00442-2

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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A 37‐Year‐Old Woman With Left Sensomotor Seizure

Belaz, Sorya ; Chiforeanu, Dan ; Devaux, Jean‐Maxime ; [et al.]

Wiley ; 2019

In: Brain Pathology Vol. 29, No. 4 ( 2019-07), p. 577-578

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In: Brain Pathology, Wiley, Vol. 29, No. 4 ( 2019-07), p. 577-578

Type of Medium: Online Resource

ISSN: 1015-6305 , 1750-3639

URL: Issue

URL: Article

DOI: 10.1111/bpa.2019.29.issue-4

DOI: 10.1111/bpa.12751

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2029927-8

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