In:
Journal of Materials Chemistry B, Royal Society of Chemistry (RSC), Vol. 9, No. 43 ( 2021), p. 8971-8979
Abstract:
Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterial-mediated antioxidant therapy is regarded as a promising strategy to treat oxidative stress-mediated inflammation. Herein, defective Ag–In–S/ZnS quantum dots (AIS/ZnS QDs) with oxygen-derived radical-scavenging capabilities are developed. Owing to their intrinsic defects and abundant surface functional groups, these quantum dots exhibit excellent oxygen-derived free radical removal efficiency in vitro . In macrophages, AIS/ZnS QDs can eliminate intracellular excessive ROS stimulated by either H 2 O 2 or lipopolysaccharide (LPS), thus can effectively protect macrophages against ROS-induced oxidative injury. Moreover, in the model of LPS-triggered macrophage inflammation, they exhibit benign anti-inflammatory ability by inhibiting the expression of related proinflammatory cytokines ( e.g. , TNF-α and IL-6). These findings indicate that AIS/ZnS QDs hold great potential for the treatment of ROS-related inflammatory disorders.
Type of Medium:
Online Resource
ISSN:
2050-750X
,
2050-7518
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2021
detail.hit.zdb_id:
2702241-9
detail.hit.zdb_id:
2705149-3
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