In:
Chemistry & Biodiversity, Wiley
Abstract:
Five psoralen derivatives were synthesized and the structures of them were characterized by 1 H‐NMR, 13 C‐NMR, and IR. The antioxidant properties of the compounds were tested by inhibiting the free radical‐initiated DNA oxidation and scavenging the radical reaction. The results showed that the effective stoichiometric factors ( n ) of the compounds V and IV could reach 2.00 and 2.11 in the system of inhibiting the DNA oxidation reaction initiated by 2,2′‐Azobis(2‐methylpropionamidine) dihydrochloride (AAPH). In the inhibition of ⋅OH‐oxidation of the DNA system, compounds I ~ V showed antioxidant properties. The thiobarbituric acid absorbance (TBARS) percentages of compounds IV and V were 76.19 % and 78.84 %. Compounds I ~ V could also inhibit Cu 2+ /GSH‐oxidation of DNA, and all compounds exhibited good antioxidant properties except compound II (94.00 %). All the five compounds were able to trap diammonium 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonate) salt radical (ABTS + ⋅), 2,2‐diphenyl‐1‐picrylhydrazyl radical (DPPH⋅) and 2,6‐di‐tert‐butyl‐alpha‐(3,5‐di‐tert‐butyl‐4‐oxo‐2,5‐cyclohexadien‐ p‐ tolylox radical (galvinoxyl⋅). The ability of compounds I ~ V to scavenge those free radicals can be measured by the k values. The k values ranged from 0.07 to 0.82 in scavenging ABTS + ⋅, galvinoxyl, and DPPH radicals, respectively.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202300620
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2139001-0
SSG:
12
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