In:
Current Pharmaceutical Design, Bentham Science Publishers Ltd., Vol. 27, No. 40 ( 2021-11-10), p. 4133-4139
Abstract:
It has been suggested that hydroxychloroquine may have positive effects on LDL-C,
HDL-C, and triglyceride levels; however, the hypolipidemic activities of this drug are still uncertain. Objective: The aim of this meta-analysis of randomized controlled trials was to explore the effect of hydroxychloroquine
on circulating lipid concentrations. Methods: Randomized controlled trials examining the impact of hydroxychloroquine on lipid parameters were
searched in PubMed, Web of Science, Scopus, and Google Scholar databases. Meta-analysis was performed using a random-effects model and sensitivity analysis through the leave one-out method. Results: Meta-analysis showed that patients receiving hydroxychloroquine therapy significantly decreased total
cholesterol (WMD: 0.18 mmol/L, 95% CI: -0.28, -0.08, I 2 = 6%, p = 0.0004), LDL-C (WMD: -0.21 mmol/L,
95% CI: -0.36, -0.06, I 2 = 75%, p = 0.006), triglycerides (WMD: -0.09 mmol/L, 95% CI: -0.15, -0.04, I 2 = 22%,
p = 0.001), and non-HDL-C (WMD: -0.28 mmol/L, 95% CI: -0.45, -0.12, I 2 = 0%, p = 0.0009), and increased
HDL-C concentrations (WMD: 0.03 mmol/L, 95% CI: 0.00, 0.06, I 2 = 0%, p = 0.03). Conclusion: Our results suggest that hydroxychloroquine improves lipid parameters by reducing total cholesterol,
LDL-C, triglycerides, non-HDL-C, and increasing HDL-C levels.
Type of Medium:
Online Resource
ISSN:
1381-6128
DOI:
10.2174/1381612827666210625162612
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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