In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-4), p. e0245844-
Abstract:
Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders. Methods Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH). Results Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10 −3 mm 2 /sec), followed by NAWM (0.808 ± 0.163 10 −3 mm 2 /sec), CE-L (0.853 ± 0.211 10 −3 mm 2 /sec), BH (0.957 ± 0.304 10 −3 mm 2 /sec) and FLAIR-L (0.976 ± 0.35 10 −3 mm 2 /sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not. Conclusion MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245844
DOI:
10.1371/journal.pone.0245844.g001
DOI:
10.1371/journal.pone.0245844.g002
DOI:
10.1371/journal.pone.0245844.g003
DOI:
10.1371/journal.pone.0245844.g004
DOI:
10.1371/journal.pone.0245844.t001
DOI:
10.1371/journal.pone.0245844.t002
DOI:
10.1371/journal.pone.0245844.t003
DOI:
10.1371/journal.pone.0245844.t004
DOI:
10.1371/journal.pone.0245844.s001
DOI:
10.1371/journal.pone.0245844.s002
DOI:
10.1371/journal.pone.0245844.s003
DOI:
10.1371/journal.pone.0245844.r001
DOI:
10.1371/journal.pone.0245844.r002
DOI:
10.1371/journal.pone.0245844.r003
DOI:
10.1371/journal.pone.0245844.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Bookmarklink