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Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Liu, Jiamin ; Li, Yan ; Ge, Jinzhuo ; [et al.]

Elsevier BV ; 2024

In: The Lancet Vol. 404, No. 10449 ( 2024-07), p. 245-255

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In: The Lancet, Elsevier BV, Vol. 404, No. 10449 ( 2024-07), p. 245-255

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(24)01028-6

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

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Layered γ-zirconium phosphate a new matrix for immobilization of hemoglobin

Geng, Li Na ; Li, Na ; Dai, Nan ; [et al.]

Elsevier BV ; 2003

In: Colloids and Surfaces B: Biointerfaces Vol. 29, No. 1 ( 2003-05), p. 81-88

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In: Colloids and Surfaces B: Biointerfaces, Elsevier BV, Vol. 29, No. 1 ( 2003-05), p. 81-88

Type of Medium: Online Resource

ISSN: 0927-7765

URL: Article

DOI: 10.1016/S0927-7765(02)00182-0

Language: English

Publisher: Elsevier BV

Publication Date: 2003

detail.hit.zdb_id: 1500523-9

SSG: 12

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Determination of Iron Liposome/Water Partition Coefficients and Identification of Influencing Factors

LI, Ni-Na. ; 〈sup〉1〈/sup〉 河北师范大学化学与材料科学学院,石家庄050024,〈sup〉1〈/sup〉 College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China ; GENG, Li-Na. ; [et al.]

Acta Physico-Chimica Sinica & University Chemistry Editorial Office, Peking University ; 2015

In: Acta Physico-Chimica Sinica Vol. 31, No. 11 ( 2015), p. 2043-2048

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In: Acta Physico-Chimica Sinica, Acta Physico-Chimica Sinica & University Chemistry Editorial Office, Peking University, Vol. 31, No. 11 ( 2015), p. 2043-2048

Type of Medium: Online Resource

ISSN: 1000-6818

URL: Article

DOI: 10.3866/PKU.WHXB201509141

Language: English

Publisher: Acta Physico-Chimica Sinica & University Chemistry Editorial Office, Peking University

Publication Date: 2015

detail.hit.zdb_id: 2474339-2

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Early argatroban and antiplatelet combination therapy in acute non-lacunar single subcortical infarct associated with mild intracranial atherosclerosis

Wang, Peng-Fei ; Sun, Zhuo-Ran ; Yu, Jin-Chao ; [et al.]

Springer Science and Business Media LLC ; 2021

In: BMC Neurology Vol. 21, No. 1 ( 2021-12)

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In: BMC Neurology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)

Abstract: Patients with acute non-lacunar single subcortical infarct (SSI) associated with mild intracranial atherosclerosis (ICAS) have a relatively high incidence of early neurological deterioration (END), resulting in unfavorable functional outcomes. Whether the early administration of argatroban and aspirin or clopidogrel within 6–12 h after symptom onset is effective and safe in these patients is unknown. Methods A review of the stroke database of Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University and Qingdao Center Hospital, Qingdao University Medical College in China was undertaken from May 2017 to January 2020 to identify all patients with non-lacunar SSI caused by ICAS within 6–12 h of symptom onset based on MRI screening. Patients were divided into two groups, one comprising those who received argatroban and mono antiplatelet therapy with aspirin or clopidogrel on admission (argatroban group), and the other those who received dual antiplatelet therapy (DAPT) with aspirin and clopidogrel during hospitalization (DAPT group). The primary outcome was recovery by 90 days after stroke based on a modified Rankin scale (mRS) score (0 to 1). The secondary outcome was END incidence within 120 h of admission. Safety outcomes were intracranial hemorrhage (ICH) and major extracranial bleeding. The probability of clinical benefit (mRS score 0–1 at 90 days) was estimated using multivariable logistic regression analysis. Results A total of 304 acute non-lacunar SSI associated with mild ICAS patients were analyzed. At 90 days, 101 (74.2%) patients in the argatroban group and 80 (47.6%) in the DAPT group had an mRS score that improved from 0 to 1 ( P 〈 0.001). The relative risk (95% credible interval) for an mRS score improving from 0 to 1 in the argatroban group was 1.50 (1.05–2.70). END occurred in 10 (7.3%) patients in the argatroban group compared with 37 (22.0%) in the DAPT group ( P 〈 0.001). No patients experienced symptomatic hemorrhagic transformation. Conclusions Early combined administration of argatroban and an antiplatelet agent (aspirin or clopidogrel) may be beneficial for patients with non-lacunar SSI associated with mild ICAS identified by MRI screening and may attenuate progressive neurological deficits. Trial registration Our study is a retrospectively registered trial.

Type of Medium: Online Resource

ISSN: 1471-2377

URL: Article

DOI: 10.1186/s12883-021-02435-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2041347-6

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The Genomes of Oryza sativa: A History of Duplications

Yu, Jun ; Wang, Jun ; Lin, Wei ; [et al.]

Public Library of Science (PLoS) ; 2005

In: PLoS Biology Vol. 3, No. 2 ( 2005-2-1), p. e38-

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In: PLoS Biology, Public Library of Science (PLoS), Vol. 3, No. 2 ( 2005-2-1), p. e38-

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.0030038

DOI: 10.1371/journal.pbio.0030038.g001

DOI: 10.1371/journal.pbio.0030038.g002

DOI: 10.1371/journal.pbio.0030038.g003

DOI: 10.1371/journal.pbio.0030038.g004

DOI: 10.1371/journal.pbio.0030038.g005

DOI: 10.1371/journal.pbio.0030038.g006

DOI: 10.1371/journal.pbio.0030038.g007

DOI: 10.1371/journal.pbio.0030038.g008

DOI: 10.1371/journal.pbio.0030038.g009

DOI: 10.1371/journal.pbio.0030038.g010

DOI: 10.1371/journal.pbio.0030038.t001

DOI: 10.1371/journal.pbio.0030038.t002

DOI: 10.1371/journal.pbio.0030038.t003

DOI: 10.1371/journal.pbio.0030038.t004

DOI: 10.1371/journal.pbio.0030038.t005

DOI: 10.1371/journal.pbio.0030038.t006

DOI: 10.1371/journal.pbio.0030038.sg001

DOI: 10.1371/journal.pbio.0030038.sg002

DOI: 10.1371/journal.pbio.0030038.sg003

DOI: 10.1371/journal.pbio.0030038.sg004

DOI: 10.1371/journal.pbio.0030038.sg005

DOI: 10.1371/journal.pbio.0030038.sg006

DOI: 10.1371/journal.pbio.0030038.sg007

DOI: 10.1371/journal.pbio.0030038.sg008

DOI: 10.1371/journal.pbio.0030038.sg009

DOI: 10.1371/journal.pbio.0030038.st001

DOI: 10.1371/journal.pbio.0030038.st002

DOI: 10.1371/journal.pbio.0030038.st003

DOI: 10.1371/journal.pbio.0030038.st004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2005

detail.hit.zdb_id: 2126773-X

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Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial

Li, Mei-feng ; Li, Xiao-li ; Fan, Kai-liang ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Journal of Hematology & Oncology Vol. 10, No. 1 ( 2017-12)

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In: Journal of Hematology & Oncology, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2017-12)

Type of Medium: Online Resource

ISSN: 1756-8722

URL: Article

DOI: 10.1186/s13045-017-0476-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2429631-4

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Deep Neural Networks Offer Morphologic Classification and Diagnosis of Bacterial Vaginosis

Wang, Zhongxiao ; Zhang, Lei ; Zhao, Min ; [et al.]

American Society for Microbiology ; 2021

In: Journal of Clinical Microbiology Vol. 59, No. 2 ( 2021-01-21)

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In: Journal of Clinical Microbiology, American Society for Microbiology, Vol. 59, No. 2 ( 2021-01-21)

Abstract: Bacterial vaginosis (BV) is caused by the excessive and imbalanced growth of bacteria in vagina, affecting 30 to 50% of women. Gram staining followed by Nugent scoring based on bacterial morphotypes under the microscope is considered the gold standard for BV diagnosis; this method is often labor-intensive and time-consuming, and results vary from person to person. We developed and optimized a convolutional neural network (CNN) model and evaluated its ability to automatically identify and classify three categories of Nugent scores from microscope images. The CNN model was first established with a panel of microscopic images with Nugent scores determined by experts. The model was trained by minimizing the cross-entropy loss function and optimized by using a momentum optimizer. The separate test sets of images collected from three hospitals were evaluated by the CNN model. The CNN model consisted of 25 convolutional layers, 2 pooling layers, and a fully connected layer. The model obtained 82.4% sensitivity and 96.6% specificity with the 5,815 validation images when altered vaginal flora and BV were considered the positive samples, which was better than the rates achieved by top-level technologists and obstetricians in China. The capability of our model for generalization was so strong that it exhibited 75.1% accuracy in three categories of Nugent scores on the independent test set of 1,082 images, which was 6.6% higher than the average of three technologists, who are hold bachelor’s degrees in medicine and are qualified to make diagnostic decisions. When three technologists ran one specimen in triplicate, the precision of three categories of Nugent scores was 54.0%. One hundred three samples diagnosed by two technologists on different days showed a repeatability of 90.3%. The CNN model outperformed human health care practitioners in terms of accuracy and stability for three categories of Nugent score diagnosis. The deep learning model may offer translational applications in automating diagnosis of bacterial vaginosis with proper supporting hardware.

Type of Medium: Online Resource

ISSN: 0095-1137 , 1098-660X

URL: Article

DOI: 10.1128/JCM.02236-20

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2021

detail.hit.zdb_id: 1498353-9

SSG: 12

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Isolation and Characterization of Three Bacterium Strains for Biodegradation of Methamidophos

Li, Dan Dan ; Yuan, Yong Ze ; Chen, Yuan Lei ; [et al.]

Trans Tech Publications, Ltd. ; 2014

In: Advanced Materials Research Vol. 955-959 ( 2014-6), p. 235-238

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In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 955-959 ( 2014-6), p. 235-238

Abstract: In this study, three bacterium strains capable of degrading methamidophos (MAP) were isolated from the soil samples contaminated with organophosphorus pesticides (OPs). According to morphological characteristics, physiological properties, and 16S rDNA sequence analysis, the isolates HS-A32, HS-D36, and HS-D38 were identified as Acinetobacter sp ., Pseudomonas stutzeri and Pseudomonas aeruginosa , respectively. They could utilize MAP as the sole carbon and nitrogen source, and the degradation ratio upon 500 mg/L MAP could reach 80% in 3 days under optimal conditions (pH 7.0, 30-35 °C). The strains could use glucose, fructose, ethanol, and galactose as carbon and energy sources, and the favorable nitrogen source included organic and inorganic nitrogen. Further studies showed that the three strains could degrade various OPs. The characterized strains with broad-spectrum OP-degrading activities could be useful for the biodegradation of MAP and the other OPs.

Type of Medium: Online Resource

ISSN: 1662-8985

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/AMR.955-959

DOI: 10.4028/www.scientific.net/AMR.955-959.235

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2014

detail.hit.zdb_id: 2265002-7

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Prognostic significance of CNSL at diagnosis of childhood B-cell acute lymphoblastic leukemia: A report from the South China Children’s Leukemia Group

Xu, Lu-Hong ; Geng, Xu ; Liao, Ning ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Oncology Vol. 12 ( 2022-8-10)

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In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-8-10)

Abstract: The prognostic significance of acute lymphoblastic leukemia (ALL) patients with central nervous system leukemia (CNSL) at diagnosis is controversial. We aimed to determine the impact of CNSL at diagnosis on the clinical outcomes of childhood B-cell ALL in the South China Children’s Leukemia Group (SCCLG). Methods A total of 1,872 childhood patients were recruited for the study between October 2016 and July 2021. The diagnosis of CNSL depends on primary cytological examination of cerebrospinal fluid, clinical manifestations, and imaging manifestations. Patients with CNSL at diagnosis received two additional courses of intrathecal triple injections during induction. Results The frequency of CNLS at the diagnosis of B-cell ALL was 3.6%. Patients with CNSL at diagnosis had a significantly higher mean presenting leukocyte count ( P = 0.002) and poorer treatment response ( P & lt; 0.05) compared with non-CNSL patients. Moreover, CNSL status was associated with worse 3-year event-free survival ( P = 0.030) and a higher risk of 3-year cumulative incidence of relapse ( P = 0.008), while no impact was observed on 3-year overall survival ( P = 0.837). Multivariate analysis revealed that CNSL status at diagnosis was an independent predictor with a higher cumulative incidence of relapse (hazard ratio = 2.809, P = 0.016). Conclusion CNSL status remains an adverse prognostic factor in childhood B-cell ALL, indicating that additional augmentation of CNS-directed therapy is warranted for patients with CNSL at diagnosis.

Type of Medium: Online Resource

ISSN: 2234-943X

URL: Article

DOI: 10.3389/fonc.2022.943761

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2649216-7

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Thermal Performance Investigation on the Boarding Bridge of Beijing’s Capital Airport

Yang, Fengguang ; Chen, Chao ; Li, Yaru ; [et al.]

Elsevier BV ; 2017

In: Procedia Engineering Vol. 205 ( 2017), p. 1967-1974

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In: Procedia Engineering, Elsevier BV, Vol. 205 ( 2017), p. 1967-1974

Type of Medium: Online Resource

ISSN: 1877-7058

URL: Article

DOI: 10.1016/j.proeng.2017.10.059

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2509658-8

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