In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2021-8-3), p. e1009685-
Abstract:
Gap junction (GJ) proteins, the primary constituents of GJ channels, are conserved determinants of patterning. Canonically, a GJ channel, made up of two hemi-channels contributed by the neighboring cells, facilitates transport of metabolites/ions. Here we demonstrate the involvement of GJ proteins during cuboidal to squamous epithelial transition displayed by the anterior follicle cells (AFCs) from Drosophila ovaries. Somatically derived AFCs stretch and flatten when the adjacent germline cells start increasing in size. GJ proteins, Innexin2 (Inx2) and Innexin4 (Inx4), functioning in the AFCs and germline respectively, promote the shape transformation by modulating calcium levels in the AFCs. Our observations suggest that alterations in calcium flux potentiate STAT activity to influence actomyosin-based cytoskeleton, possibly resulting in disassembly of adherens junctions. Our data have uncovered sequential molecular events underlying the cuboidal to squamous shape transition and offer unique insight into how GJ proteins expressed in the neighboring cells contribute to morphogenetic processes.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009685
DOI:
10.1371/journal.pgen.1009685.g001
DOI:
10.1371/journal.pgen.1009685.g002
DOI:
10.1371/journal.pgen.1009685.g003
DOI:
10.1371/journal.pgen.1009685.g004
DOI:
10.1371/journal.pgen.1009685.g005
DOI:
10.1371/journal.pgen.1009685.g006
DOI:
10.1371/journal.pgen.1009685.g007
DOI:
10.1371/journal.pgen.1009685.g008
DOI:
10.1371/journal.pgen.1009685.g009
DOI:
10.1371/journal.pgen.1009685.s001
DOI:
10.1371/journal.pgen.1009685.s002
DOI:
10.1371/journal.pgen.1009685.s003
DOI:
10.1371/journal.pgen.1009685.s004
DOI:
10.1371/journal.pgen.1009685.s005
DOI:
10.1371/journal.pgen.1009685.s006
DOI:
10.1371/journal.pgen.1009685.s007
DOI:
10.1371/journal.pgen.1009685.s008
DOI:
10.1371/journal.pgen.1009685.s009
DOI:
10.1371/journal.pgen.1009685.s010
DOI:
10.1371/journal.pgen.1009685.s011
DOI:
10.1371/journal.pgen.1009685.s012
DOI:
10.1371/journal.pgen.1009685.s013
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
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