In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-7), p. e0277378-
Abstract:
Genetic Risk Scores (GRS) for predicting dementia risk have mostly been used in people of European ancestry with limited testing in other ancestry groups. Methods We conducted a logistic regression with all-cause dementia as the outcome and z-standardised GRS as the exposure across diverse ethnic groups. Findings There was variation in frequency of APOE alleles across ethnic groups. Per standard deviation (SD) increase in z-GRS including APOE, the odds ratio (OR) for dementia was 1.73 (95%CI 1.69–1.77). Z-GRS excluding APOE also increased dementia risk (OR 1.21 per SD increase, 95% CI 1.18–1.24) and there was no evidence that ethnicity modified this association. Prediction of secondary outcomes was less robust in those not of European ancestry when APOE was excluded from the GRS. Interpretation z-GRS derived from studies in people of European ancestry can be used to quantify genetic risk in people from more diverse ancestry groups. Urgent work is needed to include people from diverse ancestries in future genetic risk studies to make this field more inclusive.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0277378
DOI:
10.1371/journal.pone.0277378.t001
DOI:
10.1371/journal.pone.0277378.t002
DOI:
10.1371/journal.pone.0277378.t003
DOI:
10.1371/journal.pone.0277378.s001
DOI:
10.1371/journal.pone.0277378.s002
DOI:
10.1371/journal.pone.0277378.s003
DOI:
10.1371/journal.pone.0277378.s004
DOI:
10.1371/journal.pone.0277378.s005
DOI:
10.1371/journal.pone.0277378.s006
DOI:
10.1371/journal.pone.0277378.r001
DOI:
10.1371/journal.pone.0277378.r002
DOI:
10.1371/journal.pone.0277378.r003
DOI:
10.1371/journal.pone.0277378.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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