In:
Clinical Chemistry and Laboratory Medicine (CCLM), Walter de Gruyter GmbH, Vol. 42, No. 3 ( 2004-01-9)
Abstract:
In acute-phase response, the use of amino acids is redirected to supporting the synthesis of proteins for host defence and tissue repair. Fibrinogen is one of these proteins, and its plasma levels commonly increase in acute-phase conditions. After hepatectomy, this pattern may be modified by the variable impact of postoperative liver dysfunction. Our study was performed to specifically assess and quantify this aspect. Data were collected prospectively on 82 hepatectomized patients; 62 recovered normally, 20 had major complications (most commonly sepsis). Plasma fibrinogen and a large series of complementary variables were determined preoperatively and at postoperative days 1, 3 and 7 in all patients and until recovery, or death in those with complications. Multiple regression analysis showed that postoperative changes in fibrinogen (δFIB, μmol/l) were simultaneously related to the number of resected liver segments (NSEG), total bilirubin (BIL, μmol/l), aspartate aminotransferase (AST, U/l, n.v. 5–45), albumin (ALB, g/l), prothrombin activity (PA, % of standard reference), age (AGE, years) and basal preoperative fibrinogen (PFIB, μmol/l): δFIB=−0.51 (NSEG)−0.71 (Log
Type of Medium:
Online Resource
ISSN:
1437-4331
,
1434-6621
DOI:
10.1515/CCLM.2004.048
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2004
detail.hit.zdb_id:
1492732-9
SSG:
15,3
Bookmarklink