In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-23), p. e0277653-
Abstract:
To assess the associations of exposure and modifications in exposure (i.e., discontinuation on admission, initiation during hospitalization) to eight common cardiovascular therapies with the risk of in-hospital death among inpatients with coronavirus disease 2019 (COVID-19). Methods In this observational study including 838 hospitalized unvaccinated adult patients with confirmed COVID-19, the use of cardiovascular therapies was assessed using logistic regression models adjusted for potential confounders. Results No cardiovascular therapy used before hospitalization was associated with an increased risk of in-hospital death. During hospitalization, the use of diuretics (aOR 2.59 [1.68–3.98]) was associated with an increase, and the use of agents acting on the renin-angiotensin system (aOR 0.39 [0.23–0.64] ) and lipid-lowering agents (aOR 0.41 [0.24–0.68] ) was associated with a reduction in the odds of in-hospital death. Exposure modifications associated with decreased survival were the discontinuation of an agent acting on the renin-angiotensin system (aOR 4.42 [2.08–9.37]), a β-blocker (aOR 5.44 [1.16–25.46] ), a lipid-modifying agent (aOR 3.26 [1.42–7.50]) or an anticoagulant (aOR 5.85 [1.25–27.27] ), as well as the initiation of a diuretic (aOR 5.19 [2.98–9.03]) or an antiarrhythmic (aOR 6.62 [2.07–21.15] ). Exposure modification associated with improved survival was the initiation of an agent acting on the renin-angiotensin system (aOR 0.17 [0.03–0.82]). Conclusion In hospitalized and unvaccinated patients with COVID-19, there was no detrimental association of the prehospital use of any regular cardiovascular medication with in-hospital death, and these therapies should be continued as recommended.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0277653
DOI:
10.1371/journal.pone.0277653.g001
DOI:
10.1371/journal.pone.0277653.g002
DOI:
10.1371/journal.pone.0277653.t001
DOI:
10.1371/journal.pone.0277653.t002
DOI:
10.1371/journal.pone.0277653.t003
DOI:
10.1371/journal.pone.0277653.t004
DOI:
10.1371/journal.pone.0277653.t005
DOI:
10.1371/journal.pone.0277653.s001
DOI:
10.1371/journal.pone.0277653.s002
DOI:
10.1371/journal.pone.0277653.s003
DOI:
10.1371/journal.pone.0277653.s004
DOI:
10.1371/journal.pone.0277653.s005
DOI:
10.1371/journal.pone.0277653.s006
DOI:
10.1371/journal.pone.0277653.s007
DOI:
10.1371/journal.pone.0277653.s008
DOI:
10.1371/journal.pone.0277653.s009
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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