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  • 1
    In: The Astrophysical Journal Letters, American Astronomical Society, Vol. 951, No. 1 ( 2023-07-01), p. L11-
    Abstract: The 15 yr pulsar timing data set collected by the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) shows positive evidence for the presence of a low-frequency gravitational-wave (GW) background. In this paper, we investigate potential cosmological interpretations of this signal, specifically cosmic inflation, scalar-induced GWs, first-order phase transitions, cosmic strings, and domain walls. We find that, with the exception of stable cosmic strings of field theory origin, all these models can reproduce the observed signal. When compared to the standard interpretation in terms of inspiraling supermassive black hole binaries (SMBHBs), many cosmological models seem to provide a better fit resulting in Bayes factors in the range from 10 to 100. However, these results strongly depend on modeling assumptions about the cosmic SMBHB population and, at this stage, should not be regarded as evidence for new physics. Furthermore, we identify excluded parameter regions where the predicted GW signal from cosmological sources significantly exceeds the NANOGrav signal. These parameter constraints are independent of the origin of the NANOGrav signal and illustrate how pulsar timing data provide a new way to constrain the parameter space of these models. Finally, we search for deterministic signals produced by models of ultralight dark matter (ULDM) and dark matter substructures in the Milky Way. We find no evidence for either of these signals and thus report updated constraints on these models. In the case of ULDM, these constraints outperform torsion balance and atomic clock constraints for ULDM coupled to electrons, muons, or gluons.
    Type of Medium: Online Resource
    ISSN: 2041-8205 , 2041-8213
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2023
    detail.hit.zdb_id: 2207648-7
    detail.hit.zdb_id: 2006858-X
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  • 2
    Online Resource
    Online Resource
    American Society of Clinical Oncology (ASCO) ; 2018
    In:  Journal of Clinical Oncology Vol. 36, No. 7_suppl ( 2018-03-01), p. 159-159
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 36, No. 7_suppl ( 2018-03-01), p. 159-159
    Abstract: 159 Background: Unmet physical, psychosocial, and other support needs of cancer survivors may lead to increased distress, anxiety, and decreased quality of life. Survivorship Clinics may be tailored for specific issues identified through a needs assessment. Methods: An invitation to complete a web-based survey was mailed to 35,420 active patients at a comprehensive cancer center in November 2015. The survey domains included demographics, cancer history, comorbidities, lifestyle, cancer prevention, spiritual and emotional support, symptom management, and interest in specific services. Results: 1,054 surveys were completed. The majority of respondents were female (55.2%; n = 582/1054), had Stage I cancer at diagnosis (43.9%; n = 360/820), and had completed treatment (69.0%; n = 727/1054). Genitourinary (23.0%; n = 238/1034) and breast (20.5%; n = 212/1034) were the most common cancer types among the respondents. Participants identified an average of 4.60 side effects experienced during or after treatment (n = 804); the most common were fatigue (64.5%), pain (37.3%), weight change (33.4%), sleep disturbance (30.2%), and gastrointestinal problems (29.4%). One third of participants reported having a physical side effect that caused anxiety and emotional distress (33.3%; n = 331/995), in particular, sexual function (69.7%; n = 136/195) and cognitive dysfunction (43.6%; n = 85/195). A total of 23.9% of participants had financial concerns due to costs of cancer treatment (n = 238/955). Participants were interested in integrative therapies, most notably yoga (75.1%; n = 289/385), acupuncture (72.4%; n = 155/214), aerobics (62.3%; n = 240/385), Swedish massage (60.5%; n = 225/372), aromatherapy (60.2%; n = 224/372), and homeopathy (55.1%; n = 118/214). Most respondents endorsed wanting information on nutrition (81.5%; n = 380/466). Conclusions: Cancer survivors report vast physical and psychosocial needs during and after cancer treatment, and they have a high interest in nutrition education and integrative therapies. Improved care coordination from a dedicated cancer survivorship and supportive care clinic at a comprehensive cancer center may specifically address survivors’ issues.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2018
    detail.hit.zdb_id: 2005181-5
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  • 3
    Online Resource
    Online Resource
    Mary Ann Liebert Inc ; 2019
    In:  The Journal of Alternative and Complementary Medicine Vol. 25, No. S1 ( 2019-03), p. S106-S111
    In: The Journal of Alternative and Complementary Medicine, Mary Ann Liebert Inc, Vol. 25, No. S1 ( 2019-03), p. S106-S111
    Type of Medium: Online Resource
    ISSN: 1075-5535 , 1557-7708
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2019
    detail.hit.zdb_id: 2030749-4
    SSG: 5,21
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  • 4
    In: Practicing Anthropology, Society for Applied Anthropology, Vol. 38, No. 4 ( 2016-09-01), p. 12-58
    Type of Medium: Online Resource
    ISSN: 0888-4552
    Language: English
    Publisher: Society for Applied Anthropology
    Publication Date: 2016
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  • 5
    In: Cancer, Wiley, Vol. 129, No. S19 ( 2023-10), p. 3162-3170
    Abstract: Qualitative data were used to understand potential sources of inequity related to breast cancer. Findings were presented to a community task force to set future priorities for addressing breast cancer disparities and increasing breast health equity in the Western New York community.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2024
    In:  Journal of Cancer Survivorship Vol. 18, No. 1 ( 2024-02), p. 11-16
    In: Journal of Cancer Survivorship, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2024-02), p. 11-16
    Abstract: Roswell Park Comprehensive Cancer Center (Roswell) is the only NCI-designated cancer center in New York State outside of the New York City metropolitan area. The Cancer Screening and Survivorship Program combines cancer screening services with survivorship care in a freestanding centralized clinic with providers also dispersed to see survivors in other clinical areas. The aims of the program are to provide comprehensive, patient-centered care to cancer survivors and their families and caregivers by addressing symptoms, supporting wellness, prevention and quality of life, and engaging community primary care providers in a shared-care model. The clinic is led by an onco-generalist, defined as an internal medicine trained physician serving cancer survivor’s medical issues from all cancer disease sites. Roswell’s Cancer Screening and Survivorship Program growth and development is guided by ongoing research related to patient needs and barriers to care, overall quality of life, health promotion and prevention, as well as education and training to build a more robust cancer survivorship workforce. The cancer center leadership has identified the expansion of cancer survivorship paired with community outreach and engagement, PCP outreach and education, and comprehensive cancer screening services as one of the key strategic areas of growth over the next decade. With the investment in our long-term strategic plan, we expect to continue to grow and serve a broader community of cancer survivors and further our research related to the structure and outcomes of our programmatic activities. Implications for Cancer Survivors This program provides robust whole-person care for cancer survivors and provides an example of successful infrastructure for cancer survivorship.
    Type of Medium: Online Resource
    ISSN: 1932-2259 , 1932-2267
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2388888-X
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  • 7
    In: Cancers, MDPI AG, Vol. 14, No. 6 ( 2022-03-10), p. 1428-
    Abstract: Therapeutic advancements in neuroendocrine tumors (NETs) have improved survival outcomes. This study aims to review the impact of the current therapeutics on health-related quality of life (HRQoL) in NET patients. A literature review was performed utilizing PubMed, The Cochrane Library, and EMBASE, using the keywords “Carcinoid”, “Neuroendocrine tumor”, “NET”, “Quality of life”, “Chemotherapy”, “Chemoembolization”, “Radiofrequency ablation”, “Peptide receptor radionucleotide therapy”, “PRRT”, “Surgery”, “Everolimus”, “Octreotide”, “Lanreotide”, “Sunitinib”, and “Somatostatin analog”. Letters, editorials, narrative reviews, case reports, and studies not in English were excluded. Out of 2375 publications, 61 studies met our inclusion criteria. The commonly used instruments were EORTC QLQ-C30, FACT G, and EORTC- QLQ GI.NET-21. HRQoL was assessed in all pivotal trials that led to approvals of systemic therapies. All systemic therapies showed no worsening in HRQoL. The NETTER-1 study was the only study to show a statistically significant improvement in HRQoL in several domains. The trial examining sunitinib versus placebo in pancreatic NETs showed no change in QoL, except for worsening of diarrhea. In addition to clinical outcomes, patient-reported outcomes are a key element in making appropriate treatment decisions. HRQoL data should be readily provided to patients to assist in shared decision-making.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527080-1
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  • 8
    Online Resource
    Online Resource
    Ecancer Global Foundation ; 2019
    In:  ecancermedicalscience Vol. 13 ( 2019-12-12)
    In: ecancermedicalscience, Ecancer Global Foundation, Vol. 13 ( 2019-12-12)
    Type of Medium: Online Resource
    ISSN: 1754-6605
    Language: Unknown
    Publisher: Ecancer Global Foundation
    Publication Date: 2019
    detail.hit.zdb_id: 2411874-6
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  • 9
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 6_Supplement_1 ( 2020-06-01), p. B105-B105
    Abstract: Background: Colorectal cancer (CRC) screening is effective in preventing and detecting cancer at an early stage, yet CRC continues to be the second leading cause of cancer death, and populations served by Federally Qualified Health Centers (FQHCs) are screened at lower rates (39%) than the national average (67%), with the lowest screening rates recent immigrants (34%). Time constraints impede providers from discussing CRC screening; insufficient access to screening facilities and patients' fear regarding colonoscopy preparation and procedure are just some of the challenges CHCs face. These issues are only compounded by significant language and cultural barriers. Methods: This quality improvement (QI) initiative measured CRC screening rates from August 2016 to April 2018 at an urban FQHC providing primary care services to diverse, low-income, and predominantly non-English speaking population with two clinic locations (intervention and control site). The patient navigator assigned to the intervention site provided both provider and patient education, developed culturally tailored patient education materials (visual), assisted in scheduling and coordinating services (transportation, interpreters, obtaining prep solution for colonoscopy) and distributed fecal immunochemical testing (FIT) for those refusing or ineligible for a colonoscopy. Our rationale for the project, supported by preliminary data, was that FQHC providers want to increase screening rates, particularly in non-English speaking patients, but need tools and support to implement change. Results: Between August 2016 and April 2018, the intervention site increased from 32% to 59% of eligible patients screened for CRC, with the most notable change in the non-English speaking patients, primarily Burmese, Nepali and Spanish speaking. The change in CRC screening rates at the intervention from baseline is highly significant (p & lt; 0.001), although the change from baseline in control site is also significant (p=0.020), but only in the second year. One year post intervention, there was a 24% increase in odds of participating in screening for a person at the intervention center compared to the control center. By April 2018, this effect increased significantly and the odds of participating in CRC screening are 86% higher for a person at the intervention center compared to the control center. In August 2018, intervention efforts will expand to the control site, piloting a culturally tailored educational video targeting the predominantly African American population served at the site. Conclusions: Specialized and tailored education plus navigation are effective in increasing CRC screening rates at FQHCs, particularly in non-English speaking populations. Understanding how different populations think about CRC screening informs navigation strategies on how to better promote screening in diverse populations and develop more targeted interventions. Citation Format: Kathryn M. Glaser, Tessa Flores, Miranda Lynch, Jessie Mossop, Alyssa Abrams, Carolyn Johnson, Deborah O. Erwin, Mary Reid. Providing colorectal cancer screening interventions at Federally Qualified Health Centers (FQHCs): Addressing the issues of language, culture, and health literacy through culturally tailored education and navigation [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr B105.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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  • 10
    Online Resource
    Online Resource
    American Association for Cancer Research (AACR) ; 2018
    In:  Cancer Research Vol. 78, No. 13_Supplement ( 2018-07-01), p. 5282-5282
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 78, No. 13_Supplement ( 2018-07-01), p. 5282-5282
    Abstract: Background: Colorectal cancer (CRC) screening is effective in preventing and detecting cancer at an early stage. Yet populations served by community health centers (CHCs) are screened at lower rates than the general population, and screening rates are even lower in non-English speaking populations. Time constraints during office visits often impede providers from discussing CRC screening, insufficient access to colonoscopy resources and facilities, and patients' fear regarding colonoscopy preparation and procedure are just some of the challenges CHCs face when promoting CRC screening. These issues are only compounded by significant language and cultural barriers. Methods: We conducted a quality improvement initiative that serves as a case study to measure the increase in CRC screening rates over a one year period at a CHC with two clinic locations (intervention and non-intervention site) providing primary care to diverse and low-income populations. A pilot site was selected by the CHC to test an intervention using patient education and navigation, while the second site received no direct navigation intervention. The patient navigator assigned to the intervention site provided patient education and developed new patient education materials (visual), in addition to assistance in scheduling and coordinating services (transportation, interpreters, obtaining prep solution etc.) for the actual colonoscopy, as well as distributing fecal immunochemical testing (FIT) for those refusing or ineligible for a colonoscopy. Our rationale for the project, supported by preliminary data was that CHC providers want to increase screening rates, particularly in non-English speaking patients, but need tools and support to implement change. Results: Between August 2016 and August 2017, the intervention site increased from 32% to 42% of eligible patients screened for CRC, with the most notable change in the non-English speaking patients (12% increase), primarily Burmese, Nepali and Spanish speaking, while there was only a 1% increase at the non-intervention site. Patient navigation efforts at the intervention site focused primarily on educating and navigating non-English speaking patients due to the increased barriers to understanding CRC and accessing preventative screening services. In total, 224 additional patients were screened for CRC during the intervention period with 86% of patients received screening colonoscopies over a FIT test. Conclusions: Specialized and tailored education and navigation can be effective to increase CRC screening rates at CHCs, particularly in non-English speaking populations. Understanding how different populations think about CRC screening would inform navigation strategies on how to better promote screening in diverse populations and develop more targeted interventions. Citation Format: Kathryn M. Glaser, Carly Nichols, Alyssa Abrams, Deborah O. Erwin, Mary Reid. Implementing a colorectal cancer screening program: A navigation led effort in an urban community health center [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5282.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    RVK:
    RVK:
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2018
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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