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Volumetric quantification of glioblastoma: experiences with different measurement techniques and impact on survival

Henker, Christian ; Kriesen, Thomas ; Glass, Änne ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Journal of Neuro-Oncology Vol. 135, No. 2 ( 2017-11), p. 391-402

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In: Journal of Neuro-Oncology, Springer Science and Business Media LLC, Vol. 135, No. 2 ( 2017-11), p. 391-402

Type of Medium: Online Resource

ISSN: 0167-594X , 1573-7373

URL: Article

DOI: 10.1007/s11060-017-2587-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2007293-4

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Advances toward fully automated in vivo assessment of oral epithelial dysplasia by nuclear endomicroscopy—A pilot study

Liese, Jan ; Winter, Karsten ; Glass, Änne ; [et al.]

Wiley ; 2017

In: Journal of Oral Pathology & Medicine Vol. 46, No. 10 ( 2017-11), p. 911-920

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In: Journal of Oral Pathology & Medicine, Wiley, Vol. 46, No. 10 ( 2017-11), p. 911-920

Abstract: Uncertainties in detection of oral epithelial dysplasia ( OED ) frequently result from sampling error especially in inflammatory oral lesions. Endomicroscopy allows non‐invasive, “en face” imaging of upper oral epithelium, but parameters of OED are unknown. Methods Mucosal nuclei were imaged in 34 toluidine blue‐stained oral lesions with a commercial endomicroscopy. Histopathological diagnosis showed four biopsies in “dys‐/neoplastic,” 23 in “inflammatory,” and seven in “others” disease groups. Strength of different assessment strategies of nuclear scoring, nuclear count, and automated nuclear analysis were measured by area under ROC curve ( AUC ) to identify histopathological “dys‐/neoplastic” group. Nuclear objects from automated image analysis were visually corrected. Results Best‐performing parameters of nuclear‐to‐image ratios were the count of large nuclei ( AUC =0.986) and 6‐nearest neighborhood relation ( AUC =0.896), and best parameters of nuclear polymorphism were the count of atypical nuclei ( AUC =0.996) and compactness of nuclei ( AUC =0.922). Excluding low‐grade OED , nuclear scoring and count reached 100% sensitivity and 98% specificity for detection of dys‐/neoplastic lesions. In automated analysis, combination of parameters enhanced diagnostic strength. Sensitivity of 100% and specificity of 87% were seen for distances of 6‐nearest neighbors and aspect ratios even in uncorrected objects. Correction improved measures of nuclear polymorphism only. The hue of background color was stronger than nuclear density ( AUC =0.779 vs 0.687) to detect dys‐/neoplastic group indicating that macroscopic aspect is biased. Conclusions Nuclear‐to‐image ratios are applicable for automated optical in vivo diagnostics for oral potentially malignant disorders. Nuclear endomicroscopy may promote non‐invasive, early detection of dys‐/neoplastic lesions by reducing sampling error.

Type of Medium: Online Resource

ISSN: 0904-2512 , 1600-0714

URL: Issue

URL: Article

DOI: 10.1111/jop.2017.46.issue-10

DOI: 10.1111/jop.12613

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2026385-5

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Ultrahigh-Field Quantitative MR Microscopy of the Chicken Eye In Vivo Throughout the In Ovo Period

Streckenbach, Felix ; Klose, Ronja ; Langner, Sönke ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Molecular Imaging and Biology Vol. 21, No. 1 ( 2019-2), p. 78-85

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In: Molecular Imaging and Biology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2019-2), p. 78-85

Type of Medium: Online Resource

ISSN: 1536-1632 , 1860-2002

URL: Article

DOI: 10.1007/s11307-018-1208-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2079211-6

SSG: 12

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Comment on "Effect of one-year lumacaftor-ivacaftor treatment on glucose tolerance abnormalities in cystic fibrosis patients"

Ballmann, Manfred ; Prinz, Nicole ; Glass, Aenne ; [et al.]

Elsevier BV ; 2020

In: Journal of Cystic Fibrosis Vol. 19, No. 5 ( 2020-09), p. 839-

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In: Journal of Cystic Fibrosis, Elsevier BV, Vol. 19, No. 5 ( 2020-09), p. 839-

Type of Medium: Online Resource

ISSN: 1569-1993

URL: Article

DOI: 10.1016/j.jcf.2020.04.009

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2091075-7

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Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease

Elleisy, Nagi ; Rohde, Sarah ; Huth, Astrid ; [et al.]

Baishideng Publishing Group Inc. ; 2020

In: World Journal of Gastroenterology Vol. 26, No. 18 ( 2020-5-14), p. 2194-2202

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In: World Journal of Gastroenterology, Baishideng Publishing Group Inc., Vol. 26, No. 18 ( 2020-5-14), p. 2194-2202

Type of Medium: Online Resource

ISSN: 1007-9327

URL: Article

DOI: 10.3748/wjg.v26.i18.2194

Language: Unknown

Publisher: Baishideng Publishing Group Inc.

Publication Date: 2020

detail.hit.zdb_id: 2084831-6

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Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15

Sparmann, Gisela ; Glass, Änne ; Brock, Peter ; [et al.]

American Physiological Society ; 2005

In: American Journal of Physiology-Gastrointestinal and Liver Physiology Vol. 289, No. 5 ( 2005-11), p. G842-G851

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In: American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society, Vol. 289, No. 5 ( 2005-11), p. G842-G851

Abstract: There is growing evidence that pancreatic stellate cells (PSCs) produce cytokines and take part in the regulation of inflammatory processes in the pancreas. IL-15 inhibits apoptosis of various cell populations. This study was performed to investigate whether PSCs produce IL-15 and thereby can affect lymphocytes. Primary PSCs were isolated from the rat pancreas using density gradient centrifugation. mRNA expression of IL-15 was demonstrated by RT-PCR, and IL-15 protein was analyzed by immunoblotting. Lymphocytes obtained from rat mesenterial lymph nodes were cocultured with in vitro activated PSCs. Apoptosis has been quantified by the binding of annexin V-FITC with a flow cytometer. Proliferation was monitored using [ 3 H]thymidine incorporation. PSCs express two splice variants of IL-15. The protein was detectable only in cell lysates but not in the cell culture supernatant. Cocultivation of lymphocytes with PSCs and IL-15 inhibited spontaneous lymphocyte apoptosis, and this effect was reduced by an anti-IL-15 antibody. Lymphocytes induced vice versa the proliferation and collagen production of PSCs. The inhibition of spontaneous lymphocyte apoptosis in cocultures with PSCs was at least partially mediated by cell-bound IL-15. This effect and the stimulation of PSCs by lymphocytes may lead to a circulus vitiosus, resulting in the persistence of inflammatory processes and the development of fibrosis during chronic pancreatitis.

Type of Medium: Online Resource

ISSN: 0193-1857 , 1522-1547

URL: Article

DOI: 10.1152/ajpgi.00483.2004

Language: English

Publisher: American Physiological Society

Publication Date: 2005

detail.hit.zdb_id: 1477329-6

SSG: 12

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Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model

Lange, Sandra ; Steder, Anne ; Glass, Änne ; [et al.]

Elsevier BV ; 2016

In: Biology of Blood and Marrow Transplantation Vol. 22, No. 4 ( 2016-04), p. 637-643

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In: Biology of Blood and Marrow Transplantation, Elsevier BV, Vol. 22, No. 4 ( 2016-04), p. 637-643

Type of Medium: Online Resource

ISSN: 1083-8791

URL: Article

DOI: 10.1016/j.bbmt.2016.01.021

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 3056525-X

detail.hit.zdb_id: 2057605-5

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Bioinformatics and The Virtual Cell (Bioinformatik und die Virtuelle Zelle)

Glass, Änne ; Karopka, Thomas ; Wolkenhauer, Olaf

Walter de Gruyter GmbH ; 2006

In: it - Information Technology Vol. 48, No. 1 ( 2006-1-1), p. 44-51

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In: it - Information Technology, Walter de Gruyter GmbH, Vol. 48, No. 1 ( 2006-1-1), p. 44-51

Abstract: Over the last decade, the areas of bioinformatics and genomics have identified, catalogued and characterised, at the molecular level, the components that make up the complex system of a cell. The next step is to describe how the many components interact to create the complex behaviour that underlies development and disease. The following article is to describe some of the research areas and challenges involved.

Type of Medium: Online Resource

ISSN: 2196-7032 , 1611-2776

URL: Article

DOI: 10.1524/itit.2006.48.1.44

RVK:

SQ 1100

RVK:

SA 5445

Language: English

Publisher: Walter de Gruyter GmbH

Publication Date: 2006

detail.hit.zdb_id: 2102301-3

detail.hit.zdb_id: 144419-0

detail.hit.zdb_id: 165820-7

detail.hit.zdb_id: 2028598-X

detail.hit.zdb_id: 6242-X

detail.hit.zdb_id: 1146417-3

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Avoiding Axillary Sentinel Lymph Node Biopsy after Neoadjuvant Systemic Therapy in Breast Cancer: Rationale for the Prospective, Multicentric EUBREAST-01 Trial

Reimer, Toralf ; Glass, Aenne ; Botteri, Edoardo ; [et al.]

MDPI AG ; 2020

In: Cancers Vol. 12, No. 12 ( 2020-12-09), p. 3698-

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In: Cancers, MDPI AG, Vol. 12, No. 12 ( 2020-12-09), p. 3698-

Abstract: Currently, axillary surgery for breast cancer is considered only as staging procedure, since the risk of developing metastasis depends on the biological behavior of the primary. The postsurgical therapy should be considered on the basis of biologic tumor characteristics rather than nodal involvement. Improvements in systemic treatments for breast cancer have increased the rates of pathologic complete response (pCR) in patients receiving neoadjuvant systemic therapy (NAST), offering the opportunity to de-escalate surgery in patients who have a pCR. European Breast Cancer Research Association of Surgical Trialists (EUBREAST)-01 is a clinical trial in which only patients with the highest likelihood of having a pCR after NAST (triple-negative or HER2-positive breast cancer) will be included and type of surgery will be defined according to the response to NAST rather than on the classical T (for tumor size in the breast) and N (for axillary lymph node involvement) status. In the discussed trial, axillary surgery will be eliminated completely (no axillary sentinel lymph node biopsy) for initially clinical node-negative (cN0) patients with radiologic complete remission and a breast pCR in the lumpectomy specimen. The trial design is a multicenter single-arm study with a limited number of patients (n = 267), which might give practice-changing results in a short period of time, sparing the time and the costs of a randomized comparison.

Type of Medium: Online Resource

ISSN: 2072-6694

URL: Article

DOI: 10.3390/cancers12123698

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2527080-1

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Pulmonary vein triggers play an important role in the initiation of atrial flutter: Initial results from the prospective randomized Atrial Fibrillation Ablation in Atrial Flutter (Triple A) trial

Schneider, Ralph ; Lauschke, Joerg ; Tischer, Tina ; [et al.]

Elsevier BV ; 2015

In: Heart Rhythm Vol. 12, No. 5 ( 2015-05), p. 865-871

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In: Heart Rhythm, Elsevier BV, Vol. 12, No. 5 ( 2015-05), p. 865-871

Type of Medium: Online Resource

ISSN: 1547-5271

URL: Article

DOI: 10.1016/j.hrthm.2015.01.040

Language: English

Publisher: Elsevier BV

Publication Date: 2015

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