In:
Cancer Medicine, Wiley, Vol. 6, No. 5 ( 2017-05), p. 953-961
Abstract:
Crizotinib has achieved astonishing success in advanced non‐small‐cell lung cancer ( NSCLC ) patients harboring anaplastic lymphoma kinase ( ALK ) rearrangement. However, no real‐world studies described the clinicopathological characteristics and treatment of such patients in China. Patients were consecutively collected from Sun Yat‐sen University Cancer Center. Chi‐square test was applied to explore the relationship between ALK fusion status and metastasis sites. Kaplan–Meier methods and multivariable analyses were used to estimate progression‐free survival ( PFS ). A total of 291 advanced NSCLC patients ( ALK (+), N = 97; both ALK & epidermal growth factor receptor ( EGFR ) (‐), N = 194) were enrolled. The occurrence of brain metastasis in ALK ‐positive patients was significantly higher than double‐negative ones both at baseline (26.5% vs. 16.5%, P = 0.038) and during treatment (25.8% vs. 11.9%, P = 0.003), but opposite for pleural effusion (6.2% vs. 26.9%, P 〈 0.001 at baseline; 3.1% vs. 10.3%, P = 0.031 during treatment). ALK ‐positive patients of 53.6% used crizotinib, whereas others only received chemotherapy (37.1%) or supportive care (9.3%). Usage of crizotinib prolonged PFS compared with chemotherapy in ALK ‐positive patients (median PFS 17.6 m vs. 4.8 m, P 〈 0.001). ALK ‐positive NSCLC had more brain metastasis and less pleural effusion than double‐negative ones. Crizotinib showed better PFS than chemotherapy in advanced ALK ‐positive NSCLC at any line. However, half advanced ALK ‐positive patients never received crizotinib, which was grim and need improving.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2017.6.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2659751-2
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