In:
European Journal of Organic Chemistry, Wiley, Vol. 2022, No. 34 ( 2022-09-13)
Abstract:
Benzothiazinones are a structural motif found in biologically active compounds, such as the clinical candidates BTZ‐043 and Macozinone for the treatment of tuberculosis. We describe a robust, two‐step method to synthesize 2‐amino‐substituted benzothiazinones from benzoyl thiocarbamates, which were prepared in a one‐pot procedure from benzoyl chlorides. The intramolecular cyclization and ethoxy displacement steps were also amenable to adoption in continuous flow as exemplified by select substrates.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2022.34
DOI:
10.1002/ejoc.202200684
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1475010-7
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