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Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Verhoeven, Virginie J M ; Consortium for Refractive Error and Myopia (CREAM) ; Hysi, Pirro G ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Nature Genetics Vol. 45, No. 3 ( 2013-03), p. 314-318

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 45, No. 3 ( 2013-03), p. 314-318

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.2554

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 1494946-5

SSG: 12

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Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Verhoeven, Virginie J M ; Consortium for Refractive Error and Myopia (CREAM) ; Hysi, Pirro G ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Nature Genetics Vol. 45, No. 6 ( 2013-6), p. 712-712

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 45, No. 6 ( 2013-6), p. 712-712

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng0613-712b

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 1494946-5

SSG: 12

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A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14

Solouki, Abbas M ; Verhoeven, Virginie J M ; van Duijn, Cornelia M ; [et al.]

Springer Science and Business Media LLC ; 2010

In: Nature Genetics Vol. 42, No. 10 ( 2010-10), p. 897-901

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 42, No. 10 ( 2010-10), p. 897-901

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.663

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2010

detail.hit.zdb_id: 1494946-5

SSG: 12

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Plasma GDF-15 concentration is not elevated in open-angle glaucoma

Hubens, Wouter H. G. ; Kievit, Mariëlle T. ; Berendschot, Tos T. J. M. ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 5 ( 2021-5-28), p. e0252630-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-28), p. e0252630-

Abstract: Recently, the level of growth differentiation factor 15 (GDF-15) in blood, was proposed as biomarker to detect mitochondrial dysfunction. In the current study, we evaluate this biomarker in open-angle glaucoma (OAG), as there is increasing evidence that mitochondrial dysfunction plays a role in the pathophysiology of this disease. Methods Plasma GDF-15 concentrations were measured with ELISA in 200 OAG patients and 61 age-matched controls (cataract without glaucoma). The OAG patient group consisted of high tension glaucoma (HTG; n = 162) and normal tension glaucoma (NTG; n = 38). Groups were compared using the Kruskal-Wallis nonparametric test with Dunn’s multiple comparison post-hoc correction. GDF-15 concentration was corrected for confounders identified with forward linear regression models. Results Before correcting for confounders, median plasma GDF-15 levels was significantly lower in the combined OAG group (p = 0.04), but not when analysing HTG and NTG patients separately. Forward linear regression analysis showed that age, gender, smoking and systemic hypertension were significant confounders affecting GDF-15 levels. After correction for these confounders, GDF-15 levels in OAG patients were no longer significantly different from controls. Subgroup analysis of the glaucoma patients did not show a correlation between disease severity and plasma GDF-15, but did reveal that for NTG patients, intake of dietary supplements, which potentially improve mitochondrial function, correlated with lower plasma GDF-15. Conclusion The present study suggests that plasma GDF-15 is not suited as biomarker of mitochondrial dysfunction in OAG patients.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0252630

DOI: 10.1371/journal.pone.0252630.g001

DOI: 10.1371/journal.pone.0252630.g002

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DOI: 10.1371/journal.pone.0252630.s004

DOI: 10.1371/journal.pone.0252630.s005

DOI: 10.1371/journal.pone.0252630.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

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Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits

Bertens, Christian J. F. ; van Mechelen, Ralph J. S. ; Berendschot, Tos T. J. M. ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Scientific Reports Vol. 11, No. 1 ( 2021-09-28)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-09-28)

Abstract: The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on IOP was investigated in 21 New Zealand White rabbits with the TonoVet tonometer. Repeatability was determined using the coefficient of variation (CoV) for two observers. For the TonoLab (6.55%) and TonoVet (6.38%) the CoV was lower than for the TonoPEN AVIA (10.88%). The reproducibility was highest for the TonoVet (0.2 ± 3.3 mmHg), followed by the TonoLab (0 ± 12.89 mmHg) and lowest for the TonoPEN AVIA (− 1.48 ± 10.3 mmHg). The TonoLab and TonoVet showed the highest agreement (r = 0.85, R 2 = 0.73). After sedation, a significant IOP reduction (often 〉 25%) was observed. Our results show that among the three tonometers tested, the TonoVet tonometer is best for use in rabbits while the TonoLab should be avoided. The impact of sedation on IOP was substantial and should be taken into account during experimentation.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-021-98762-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2615211-3

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Gene Expression and Functional Annotation of the Human and Mouse Choroid Plexus Epithelium

Janssen, Sarah F. ; van der Spek, Sophie J. F. ; ten Brink, Jacoline B. ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 12 ( 2013-12-31), p. e83345-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 12 ( 2013-12-31), p. e83345-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0083345

DOI: 10.1371/journal.pone.0083345.g001

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DOI: 10.1371/journal.pone.0083345.s001

DOI: 10.1371/journal.pone.0083345.s002

DOI: 10.1371/journal.pone.0083345.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

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Comprehensive bioinformatics analysis of trabecular meshwork gene expression data to unravel the molecular pathogenesis of primary open‐angle glaucoma

Liesenborghs, Ilona ; Eijssen, Lars M. T. ; Kutmon, Martina ; [et al.]

Wiley ; 2020

In: Acta Ophthalmologica Vol. 98, No. 1 ( 2020-02), p. 48-57

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In: Acta Ophthalmologica, Wiley, Vol. 98, No. 1 ( 2020-02), p. 48-57

Abstract: Performing bioinformatics analyses using trabecular meshwork ( TM ) gene expression data in order to further elucidate the molecular pathogenesis of primary open‐angle glaucoma ( POAG ), and to identify candidate target genes. Methods A systematic search in Gene Expression Omnibus and ArrayExpress was conducted, and quality control and preprocessing of the data was performed with ArrayAnalysis.org. Molecular pathway overrepresentation analysis was performed with PathVisio using pathway content from three pathway databases: WikiPathways, KEGG and Reactome. In addition, Gene Ontology ( GO ) analysis was performed on the gene expression data. The significantly changed pathways were clustered into functional categories which were combined into a network of connected genes. Results Ninety‐two significantly changed pathways were clustered into five functional categories: extracellular matrix ( ECM ), inflammation, complement activation, senescence and Rho GTP ase signalling. ECM included pathways involved in collagen, actin and cell–matrix interactions. Inflammation included pathways entailing NF ‐ κ B and arachidonic acid. The network analysis showed that several genes overlap between the inflammation cluster on the one hand, and the ECM , complement activation and senescence clusters on the other hand. GO analysis, identified additional clusters, related to development and corticosteroids. Conclusion This study provides an overview of the processes involved in the molecular pathogenesis of POAG in the TM . The results show good face validity and confirm findings from histological, biochemical, genome‐wide association and transcriptomics studies. The identification of known points of action for drugs, such as Rho GTP ase, arachidonic acid, NF ‐ κ B, prostaglandins and corticosteroid clusters, supports the value of this approach to identify potential drug targets.

Type of Medium: Online Resource

ISSN: 1755-375X , 1755-3768

URL: Issue

URL: Article

DOI: 10.1111/aos.v98.1

DOI: 10.1111/aos.14154

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 2466981-7

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The Molecular Processes in the Trabecular Meshwork After Exposure to Corticosteroids and in Corticosteroid-Induced Ocular Hypertension

Liesenborghs, Ilona ; Eijssen, Lars M. T. ; Kutmon, Martina ; [et al.]

Association for Research in Vision and Ophthalmology (ARVO) ; 2020

In: Investigative Opthalmology & Visual Science Vol. 61, No. 4 ( 2020-04-18), p. 24-

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In: Investigative Opthalmology & Visual Science, Association for Research in Vision and Ophthalmology (ARVO), Vol. 61, No. 4 ( 2020-04-18), p. 24-

Type of Medium: Online Resource

ISSN: 1552-5783

URL: Article

DOI: 10.1167/iovs.61.4.24

Language: English

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

Publication Date: 2020

detail.hit.zdb_id: 2009858-3

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Wound Healing Response After Bleb-Forming Glaucoma Surgery With a SIBS Microshunt in Rabbits

van Mechelen, Ralph J. S. ; Wolters, Jarno E. J. ; Herfs, Marjolein ; [et al.]

Association for Research in Vision and Ophthalmology (ARVO) ; 2022

In: Translational Vision Science & Technology Vol. 11, No. 8 ( 2022-08-26), p. 29-

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In: Translational Vision Science & Technology, Association for Research in Vision and Ophthalmology (ARVO), Vol. 11, No. 8 ( 2022-08-26), p. 29-

Type of Medium: Online Resource

ISSN: 2164-2591

URL: Article

DOI: 10.1167/tvst.11.8.29

Language: English

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

Publication Date: 2022

detail.hit.zdb_id: 2674602-5

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Gene Expression and Functional Annotation of the Human Ciliary Body Epithelia

Janssen, Sarah F. ; Gorgels, Theo G. M. F. ; Bossers, Koen ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS ONE Vol. 7, No. 9 ( 2012-9-18), p. e44973-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 9 ( 2012-9-18), p. e44973-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0044973

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Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2267670-3

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