In:
Molecular Plant-Microbe Interactions®, Scientific Societies, Vol. 13, No. 2 ( 2000-02), p. 203-209
Abstract:
Beticolins are toxins produced by Cercospora beticola, a phytopathogenic fungus responsible for the leaf spot disease of sugar beet. They form a family of 20 nonpeptidic compounds (named B0 to B19) that share the same polycyclic skeleton but differ by isomeric configuration (ortho- or para-) and by a variable residue R (bridging two carbons in one of the six cycles). It has been previously shown that B0 assembles itself into a multimeric structure and forms ion channels into planar lipid bilayers (C. Goudet, A.-A. Véry, M.-L. Milat, M. Ildefonse, J.-B. Thibaud, H.Sentenac, and J.-P. Blein, Plant J. 14:359-364, 1998). In the present work, we investigate pore formation by three ortho-beticolins, B0, B2, and B4, and their related (i.e., same R) para-isomers, B13, B1, and B3, respectively, using planarlipid bilayers. All beticolins were able to form ionchannels with multiple conductance states, although the type of cyclization (ortho- or para-) and residue (R) result in variations of channel conductance and ionic permeability, respectively. Channel formation by beticolins is likely to be involved in the biological activity of these toxins.
Type of Medium:
Online Resource
ISSN:
0894-0282
,
1943-7706
DOI:
10.1094/MPMI.2000.13.2.203
Language:
English
Publisher:
Scientific Societies
Publication Date:
2000
detail.hit.zdb_id:
2037108-1
SSG:
12
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