In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-7), p. e0282801-
Abstract:
Wilson’s disease may lead to cirrhosis, but timely medical treatment could slow down its progression. Clinical markers helping early diagnosis are essential. Decreased fetuin-A concentration has been reported in cirrhosis of different etiologies. The aim of this study was to investigate whether decreased serum fetuin-A concentration could identify patients with Wilson’s disease who developed cirrhosis. Materials and methods In this cross-sectional study we determined the serum fetuin-A concentration of 50 patients with Wilson’s disease. We analyzed the data of patients with liver involvement, comparing cirrhotic and non-cirrhotic patients. Results Among patients with liver involvement those with cirrhosis had significantly lower fetuin-A and albumin level, white blood cell and platelet count. Fetuin-A negatively correlated with disease duration, bilirubin level, positively with total protein and albumin concentration, but not with copper and ceruloplasmin concentrations or markers of systemic inflammation. In multivariate analysis with fetuin-A and the Nazer score or its parameters only fetuin-A was a significant determinant of having cirrhosis. In receiver operator curve analysis among patients with liver involvement the fetuin-A level of 523 μg/ml was associated with cirrhosis with 82% sensitivity and 87% specificity. The presence of the H1069Q mutation was not associated with alteration in fetuin-A concentration. Conclusions The serum concentration of fetuin-A is a sensitive marker of liver cirrhosis in Wilson’s disease, independently of the H1069Q mutation, ceruloplasmin concentration or systemic inflammation.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282801
DOI:
10.1371/journal.pone.0282801.g001
DOI:
10.1371/journal.pone.0282801.g002
DOI:
10.1371/journal.pone.0282801.t001
DOI:
10.1371/journal.pone.0282801.t002
DOI:
10.1371/journal.pone.0282801.s001
DOI:
10.1371/journal.pone.0282801.r001
DOI:
10.1371/journal.pone.0282801.r002
DOI:
10.1371/journal.pone.0282801.r003
DOI:
10.1371/journal.pone.0282801.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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