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ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

ISARIC Clinical Characterization Group ; Abbas, Ali ; Abdukahil, Sheryl Ann ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Scientific Data Vol. 9, No. 1 ( 2022-07-30)

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In: Scientific Data, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2022-07-30)

Abstract: The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.

Type of Medium: Online Resource

ISSN: 2052-4463

URL: Article

DOI: 10.1038/s41597-022-01534-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2775191-0

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Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Citarella, Barbara Wanjiru ; Kartsonaki, Christiana ; Ibáñez-Prada, Elsa D. ; [et al.]

Elsevier BV ; 2024

In: Heliyon Vol. 10, No. 10 ( 2024-05), p. e29591-

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In: Heliyon, Elsevier BV, Vol. 10, No. 10 ( 2024-05), p. e29591-

Type of Medium: Online Resource

ISSN: 2405-8440

URL: Article

DOI: 10.1016/j.heliyon.2024.e29591

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2835763-2

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Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure

Dietz, Julia ; Müllhaupt, Beat ; Buggisch, Peter ; [et al.]

Elsevier BV ; 2023

In: Journal of Hepatology Vol. 78, No. 1 ( 2023-01), p. 57-66

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In: Journal of Hepatology, Elsevier BV, Vol. 78, No. 1 ( 2023-01), p. 57-66

Type of Medium: Online Resource

ISSN: 0168-8278

URL: Article

DOI: 10.1016/j.jhep.2022.08.016

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2027112-8

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Clinical characteristics and outcome of Mycobacterium chimaera infections after cardiac surgery: systematic review and meta-analysis of 180 heater-cooler unit-associated cases

Wetzstein, Nils ; Kohl, Thomas A. ; Diricks, Margo ; [et al.]

Elsevier BV ; 2023

In: Clinical Microbiology and Infection Vol. 29, No. 8 ( 2023-08), p. 1008-1014

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In: Clinical Microbiology and Infection, Elsevier BV, Vol. 29, No. 8 ( 2023-08), p. 1008-1014

Type of Medium: Online Resource

ISSN: 1198-743X

URL: Article

DOI: 10.1016/j.cmi.2023.03.005

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2020034-1

SSG: 12

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Efficacy of Norfloxacin Prophylaxis to Prevent Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-Analysis

Mücke, Marcus M. ; Mücke, Victoria T. ; Graf, Christiana ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2020

In: Clinical and Translational Gastroenterology Vol. 11, No. 8 ( 2020-8-14), p. e00223-

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In: Clinical and Translational Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 11, No. 8 ( 2020-8-14), p. e00223-

Type of Medium: Online Resource

ISSN: 2155-384X

URL: Article

DOI: 10.14309/ctg.0000000000000223

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2020

detail.hit.zdb_id: 2581516-7

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Treatment of Non-Anastomotic Biliary Strictures after Liver Transplantation: How Effective Is Our Current Treatment Strategy?

Michael, Florian A. ; Friedrich-Rust, Mireen ; Erasmus, Hans-Peter ; [et al.]

MDPI AG ; 2023

In: Journal of Clinical Medicine Vol. 12, No. 10 ( 2023-05-16), p. 3491-

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In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 10 ( 2023-05-16), p. 3491-

Abstract: Background: Non-anastomotic biliary strictures (NAS) are a common cause of morbidity and mortality after liver transplantation. Methods: All patients with NAS from 2008 to 2016 were retrospectively analyzed. The success rate and overall mortality of an ERCP-based stent program (EBSP) were the primary outcomes. Results: A total of 40 (13.9%) patients with NAS were identified, of which 35 patients were further treated in an EBSP. Furthermore, 16 (46%) patients terminated EBSP successfully, and nine (26%) patients died during the program. All deaths were caused by cholangitis. Of those, one (11%) patient had an extrahepatic stricture, while the other eight patients had either intrahepatic (3, 33%) or combined extra- and intrahepatic strictures (5, 56%). Risk factors of overall mortality were age (p = 0.03), bilirubin (p 〈 0.0001), alanine transaminase (p = 0.006), and aspartate transaminase (p = 0.0003). The median duration of the stent program was 34 months (ITBL: 36 months; IBL: 10 months), and procedural complications were rare. Conclusions: EBSP is safe, but lengthy and successful in only about half the patients. Intrahepatic strictures were associated with an increased risk of cholangitis.

Type of Medium: Online Resource

ISSN: 2077-0383

URL: Article

DOI: 10.3390/jcm12103491

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 2662592-1

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Hepatitis C Clearance by Direct-Acting Antivirals Impacts Glucose and Lipid Homeostasis

Graf, Christiana ; Welzel, Tania ; Bogdanou, Dimitra ; [et al.]

MDPI AG ; 2020

In: Journal of Clinical Medicine Vol. 9, No. 9 ( 2020-08-21), p. 2702-

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In: Journal of Clinical Medicine, MDPI AG, Vol. 9, No. 9 ( 2020-08-21), p. 2702-

Abstract: Background: Chronic hepatitis C virus (HCV) infections are causally linked with metabolic comorbidities such as insulin resistance, hepatic steatosis, and dyslipidemia. However, the clinical impact of HCV eradication achieved by direct-acting antivirals (DAAs) on glucose and lipid homeostasis is still controversial. The study aimed to prospectively investigate whether antiviral therapy of HCV with DAAs alters glucose and lipid parameters. Methods: 50 patients with chronic HCV who were treated with DAAs were screened, and 49 were enrolled in the study. Biochemical and virological data, as well as noninvasive liver fibrosis parameters, were prospectively collected at baseline, at the end of treatment (EOT) and 12 and 24 weeks post-treatment. Results: 45 of 46 patients achieved sustained virologic response (SVR). The prevalence of insulin resistance (HOMA-IR) after HCV clearance was significantly lower, compared to baseline (5.3 ± 6.1 to 2.5 ± 1.9, p 〈 0.001), which is primarily attributable to a significant decrease of fasting insulin levels (18.9 ± 17.3 to 11.7 ± 8.7; p = 0.002). In contrast to that, HCV eradication resulted in a significant increase in cholesterol levels (total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein (HDL-C) levels) and Controlled Attenuated Score (CAP), although BMI did not significantly change over time (p = 0.95). Moreover, HOMA-IR correlated significantly with noninvasive liver fibrosis measurements at baseline und during follow-up (TE: r = 0.45; p = 0.003, pSWE: r = 0.35; p = 0.02, APRI: r = 0.44; p = 0.003, FIB-4: r = 0.41; p 〈 0.001). Conclusion: Viral eradication following DAA therapy may have beneficial effects on glucose homeostasis, whereas lipid profile seems to be worsened.

Type of Medium: Online Resource

ISSN: 2077-0383

URL: Article

DOI: 10.3390/jcm9092702

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2662592-1

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Is a higher frequency of esophageal dilations more effective in treating benign esophageal strictures: a retrospective, multicenter study

Graf, Christiana ; Reden, Monika ; Blasberg, Tobias ; [et al.]

Georg Thieme Verlag KG ; 2023

In: Endoscopy International Open

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In: Endoscopy International Open, Georg Thieme Verlag KG

Abstract: Background: There is still a lack of evidence-based recommendations concerning endoscopic bougienage in benign esophageal strictures. Our study aimed to assess the relevance of the time interval between endoscopic dilation (ED) sessions with regard to endoscopic and clinical response. Methods: We performed a retrospective study including patients treated with endoscopic bougienage for a benign esophageal stricture in 2 German centers. Primary endpoint was the number of ED until freedom from dysphagia was achieved. Secondary endpoints comprised analyses on reaching a diameter of 15mm and on achieving clinical freedom from symptoms. Results: Between April 2014 and March 2020, bougienage was used as the primary treatment of benign esophageal strictures in 238 patients (194 patients in Center 1; 44 patients in Center 2). Both centers differed in their endoscopic bougienage regime: center 1 was characterized by a higher frequency of interventions compared to center 2 (median: 2 days (range 1, 28) vs. 10 days (range 1, 41); p 〈 0.001). Clinical response was achieved significantly earlier using the high frequency regime in all patients except for those with postradiogen strictures, who clinically benefited from a low frequency ED program. Accordingly, patients receiving higher frequency ED reached a significantly larger post-dilation diameter and considerably larger diameter differences. Conclusion: The results of our study demonstrate that a treatment concept consisting of higher frequency bougienages seems to be more effective in treating most types of esophageal strictures. Radiogenic strictures were the only types of stenoses, which benefit from a lower frequency ED program.

Type of Medium: Online Resource

ISSN: 2364-3722 , 2196-9736

URL: Article

DOI: 10.1055/a-2117-8197

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2023

detail.hit.zdb_id: 2761052-4

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Disseminated disease due to non-tuberculous mycobacteria in HIV positive patients: A retrospective case control study

Wetzstein, Nils ; Geil, Ari ; Kann, Gerrit ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 7 ( 2021-7-13), p. e0254607-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 7 ( 2021-7-13), p. e0254607-

Abstract: Disseminated infection due to non-tuberculous mycobacteria has been a major factor of mortality and comorbidity in HIV patients. Until 2018, U.S. American guidelines have recommended antimycobacterial prophylaxis in patients with low CD4 cell counts, a practice that has not been adopted in Europe. This study aimed at examining the impact of disseminated NTM disease on clinical outcome in German HIV patients with a severe immunodeficiency. Materials and methods In this retrospective case control study, HIV patients with disseminated NTM disease were identified by retrospective chart review and matched by their CD4 cell counts to HIV patients without NTM infection in a 1:1 alocation. Primary endpoints were mortality and time to first rehospitalisation. In addition, other opportunistic diseases, as well as antimycobacterial and antiretroviral treatments were examined. Results Between 2006 and 2016, we identified 37 HIV patients with disseminated NTM disease. Most of them were suffering from infections due to M . avium complex ( n = 31, 77.5%). Time to event analysis showed a non-significant trend to higher mortality in patients with disseminated NTM disease (p = 0.24). Rehospitalisation took place significantly earlier in patients with disseminated NTM infections (median 40.5 days vs. 109 days, p 〈 0.0001). Conclusion In this retrospective case control study, we could demonstrate that mortality is not significantly higher in HIV patients with disseminated NTM disease in the ART era, but that they require specialised medical attention in the first months following discharge.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0254607

DOI: 10.1371/journal.pone.0254607.g001

DOI: 10.1371/journal.pone.0254607.g002

DOI: 10.1371/journal.pone.0254607.g003

DOI: 10.1371/journal.pone.0254607.t001

DOI: 10.1371/journal.pone.0254607.t002

DOI: 10.1371/journal.pone.0254607.t003

DOI: 10.1371/journal.pone.0254607.t004

DOI: 10.1371/journal.pone.0254607.r001

DOI: 10.1371/journal.pone.0254607.r002

DOI: 10.1371/journal.pone.0254607.r003

DOI: 10.1371/journal.pone.0254607.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

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THU-211-Evaluation of point shearwave elastography using acoustic radiation force impulse imaging for non-invasive assessment of liver fibrosis in HBeAg-negative chronic HBV infection: A prospective longitudinal study

Graf, Christiana ; Knop, Viola ; Mondorf, Antonia ; [et al.]

Elsevier BV ; 2019

In: Journal of Hepatology Vol. 70, No. 1 ( 2019-04), p. e256-

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In: Journal of Hepatology, Elsevier BV, Vol. 70, No. 1 ( 2019-04), p. e256-

Type of Medium: Online Resource

ISSN: 0168-8278

URL: Article

DOI: 10.1016/S0618-8278(19)30484-0

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2027112-8

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