In:
Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 104, No. 4 ( 2018-09-28), p. 821-832
Abstract:
Programmed death ligand 1 (PD-L1) (also called B7-H1) is a membrane immune-modulatory protein whose overexpression on the surface of tumor cells as well as APCs impairs T-cell-mediated killing. Viruses that establish chronic infections have developed a number of strategies to escape from immune recognition including the up-regulation of PD-L1. This study shows for the first time that the human oncovirus EBV infects human primary monocytes using HLA-DR and induced a strong up-regulation of PD-L1 expression on their surface. Searching for the underlying mechanism/s leading to this immune suppressive effect, we found that EBV activated TLR signaling, increased intracellular ROS, and phosphorylated STAT3. Targeting these molecules partially reverted PD-L1 up-regulation that correlated with an altered cytokine production and a reduction of monocyte cell survival, strongly impairing the antiviral immune response. EBV induces PD-L1 expression on the surface of infected monocytes suggesting that targeting this molecule could help to prevent or treat viral-associated diseases.
Type of Medium:
Online Resource
ISSN:
1938-3673
,
0741-5400
DOI:
10.1002/JLB.2A0118-029RR
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2018
detail.hit.zdb_id:
2026833-6
SSG:
12
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