In:
European Respiratory Journal, European Respiratory Society (ERS), Vol. 58, No. 3 ( 2021-09), p. 2003633-
Abstract:
Longitudinal evidence on the relation between dietary intake of n -3 (ω-3) very-long-chain polyunsaturated fatty acids, i.e. eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in mid-childhood and asthma risk is scarce. We aimed to investigate whether a higher intake of EPA and DHA from fish in childhood is associated with a lower risk of incident asthma. In the Avon Longitudinal Study of Parents and Children, dietary intakes of EPA and DHA from fish were estimated by food frequency questionnaire at 7 years of age. We used logistic regression, controlling for confounders, to analyse associations between intake of EPA and DHA (quartiles) and incidence of doctor-diagnosed asthma at age 11 or 14 years, and explored potential effect modification by a fatty acid desaturase ( FADS ) polymorphism (rs1535). Replication was sought in the Swedish BAMSE birth cohort. There was no evidence of association between intake of EPA plus DHA from fish and incident asthma overall (n=4543). However, when stratified by FADS genotype, the odds ratio comparing the top versus bottom quartile among the 2025 minor G allele carriers was 0.49 (95% CI 0.31–0.79; p trend =0.006), but no inverse association was observed in the homozygous major A allele group (OR 1.43, 95% CI 0.83–2.46; p trend =0.19) (p interaction =0.006). This gene–nutrient interaction on incident asthma was replicated in BAMSE. In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence.
Type of Medium:
Online Resource
ISSN:
0903-1936
,
1399-3003
DOI:
10.1183/13993003.03633-2020
DOI:
10.1183/13993003.03633-2020.Supp1
DOI:
10.1183/13993003.03633-2020.Shareable1
Language:
English
Publisher:
European Respiratory Society (ERS)
Publication Date:
2021
detail.hit.zdb_id:
2834928-3
detail.hit.zdb_id:
1499101-9
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