In:
Liver International, Wiley, Vol. 35, No. 3 ( 2015-03), p. 1036-1047
Abstract:
Sorafenib and transarterial 90 Y‐radioembolization ( TARE ) are possible treatments for Barcelona Clinic Liver Cancer ( BCLC ) intermediate‐advanced stage hepatocellular carcinoma ( HCC ). No study directly comparing sorafenib and TARE is currently available. This single‐centre retrospective study compares the outcomes achieved with sorafenib and TARE in HCC patients potentially amenable to either therapy. Methods Seventy‐four sorafenib (71 ± 10 years, male 87%, BCLC B/C 53%/47%) and 63 TARE HCC patients (66 ± 9 years, male 79%, BCLC B/C 41%/59%) were included based on the following criteria: Child–Pugh class A/B, performance status ≤1, HCC unfit for other effective therapies, no metastases and no previous systemic chemotherapy. Results Median overall survivals of the two groups were comparable, being 14.4 months (95% CI: 4.3–24.5) in sorafenib and 13.2 months (95% CI: 6.1–20.2) in TARE patients, with 1‐, 2‐ and 3‐year survival rates of 52.1%, 29.3% and 14.7% vs 51.8%, 27.8% and 21.6% respectively. Two TARE patients underwent liver transplantation after successful down‐staging. To minimize the impact of confounding factors on survival analysis, propensity model matched 32 patients of each group for median age, tumour gross pathology and the independent prognostic factors (portal vein thrombosis, performance status, Model for End Liver Disease). Even after matching, the median survival did not differ between sorafenib (13.1 months; 95% CI: 1.2–25.9) and TARE patients (11.2 months; 95% CI: 6.7–15.7), with comparable 1‐, 2‐ and 3‐year survival rates. Conclusions In cirrhotic patients with intermediate‐advanced or not‐otherwise‐treatable HCC , sorafenib and TARE provide similar survivals. Down‐staging allowing liver transplantation only occurred after TARE .
Type of Medium:
Online Resource
ISSN:
1478-3223
,
1478-3231
DOI:
10.1111/liv.2015.35.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2124684-1
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