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Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

Scott, Kenneth L. ; Nogueira, Cristina ; Heffernan, Timothy P. ; [et al.]

Elsevier BV ; 2011

In: Cancer Cell Vol. 20, No. 1 ( 2011-07), p. 92-103

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In: Cancer Cell, Elsevier BV, Vol. 20, No. 1 ( 2011-07), p. 92-103

Type of Medium: Online Resource

ISSN: 1535-6108

URL: Article

DOI: 10.1016/j.ccr.2011.05.025

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2074034-7

detail.hit.zdb_id: 2078448-X

SSG: 12

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5‐Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms

Lee, Jonathan J. ; Vilain, Ricardo E. ; Granter, Scott R. ; [et al.]

Wiley ; 2017

In: Journal of Cutaneous Pathology Vol. 44, No. 3 ( 2017-03), p. 249-255

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In: Journal of Cutaneous Pathology, Wiley, Vol. 44, No. 3 ( 2017-03), p. 249-255

Abstract: 5‐Hydroxymethylcytosine (5‐ hmC ) is an epigenetic marker detectable through immunohistochemistry ( IHC ) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was to explore its diagnostic utility in a subset of histologically challenging, heavily pigmented cutaneous melanocytic neoplasms. Methods 5‐ hmC IHC was performed on 54 heavily pigmented melanocytic tumors. Semi‐quantitative analysis of immunoreactivity was correlated with clinical, pathologic and follow‐up data. Results Benign melanocytic neoplasms (4 of 4 blue nevi with epithelioid change; 12 of 12 combined nevi; 5 of 5 deep penetrating nevi, DPN ) exhibited strong 5‐ hmC nuclear reactivity. Eight heavily pigmented blue nevus‐like melanomas and 7 of 8 pigmented epithelioid melanocytomas ( PEM ) showed significant 5‐ hmC loss. Five of 7 atypical DPN cases and 8 of 10 melanocytic tumors of uncertain malignant potential ( MELTUMP ) showed low to intermediate 5‐ hmC immunoreactivity. These differences were statistically significant ( P ‐value 〈 .0001). Conclusions Loss of 5‐ hmC may be helpful in differentiating benign, diagnostically challenging, heavily pigmented melanocytic tumors from those with malignant potential. The intermediate to low 5‐ hmC immunoreactivity in atypical DPNs , PEMs and so‐called MELTUMP categories further underscores the need to consider these neoplasms as having some potential for lethal biological behavior.

Type of Medium: Online Resource

ISSN: 0303-6987 , 1600-0560

URL: Issue

URL: Article

DOI: 10.1111/cup.2017.44.issue-3

DOI: 10.1111/cup.12880

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2018100-0

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Ipilimumab for Patients with Relapse after Allogeneic Transplantation

Davids, Matthew S. ; Kim, Haesook T. ; Bachireddy, Pavan ; [et al.]

Massachusetts Medical Society ; 2016

In: New England Journal of Medicine Vol. 375, No. 2 ( 2016-07-14), p. 143-153

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In: New England Journal of Medicine, Massachusetts Medical Society, Vol. 375, No. 2 ( 2016-07-14), p. 143-153

Type of Medium: Online Resource

ISSN: 0028-4793 , 1533-4406

URL: Article

DOI: 10.1056/NEJMoa1601202

RVK:

XA 10000

Language: English

Publisher: Massachusetts Medical Society

Publication Date: 2016

detail.hit.zdb_id: 1468837-2

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Duration of symptoms does not correlate with results of T‐cell gene rearrangement studies in patients evaluated for cutaneous T‐cell lymphoma

Larson, Allison R. ; Rodig, Scott ; Granter, Scott R.

Wiley ; 2015

In: Journal of Cutaneous Pathology Vol. 42, No. 9 ( 2015-09), p. 618-621

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In: Journal of Cutaneous Pathology, Wiley, Vol. 42, No. 9 ( 2015-09), p. 618-621

Abstract: We aimed to determine if clonality on T‐cell gene rearrangement studies correlated with duration of cutaneous symptoms in patients with skin disease who are being evaluated for cutaneous T‐cell lymphoma (CTCL). Specifically, our goal was to determine if symptom duration could help better optimize sample selection for T‐cell gene rearrangement studies. Methods Biopsies were reviewed from patients within both general dermatology clinic and CTCL specialty clinic for clonality results in relation to disease duration. Results We did not find an association between duration and clonality in any group. Conclusions The yield of T‐cell gene rearrangement studies is similar between shorter and longer duration of disease implying that there is not an optimal duration range in which T‐cell gene rearrangement studies are more likely to give a positive result.

Type of Medium: Online Resource

ISSN: 0303-6987 , 1600-0560

URL: Issue

URL: Article

DOI: 10.1111/cup.2015.42.issue-9

DOI: 10.1111/cup.12516

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2018100-0

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Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

Scott, Kenneth L. ; Nogueira, Cristina ; Heffernan, Timothy P. ; [et al.]

Elsevier BV ; 2011

In: Cancer Cell Vol. 20, No. 2 ( 2011-08), p. 277-

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In: Cancer Cell, Elsevier BV, Vol. 20, No. 2 ( 2011-08), p. 277-

Type of Medium: Online Resource

ISSN: 1535-6108

URL: Article

DOI: 10.1016/j.ccr.2011.08.005

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2074034-7

detail.hit.zdb_id: 2078448-X

SSG: 12

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Direct immunofluorescence is of limited utility in patients with low clinical suspicion for an oral autoimmune bullous disorder

Bresler, Scott C. ; Bavarian, Roxanne ; Granter, Scott R. ; [et al.]

Wiley ; 2020

In: Oral Diseases Vol. 26, No. 1 ( 2020-01), p. 81-88

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In: Oral Diseases, Wiley, Vol. 26, No. 1 ( 2020-01), p. 81-88

Abstract: Oral autoimmune bullous disorders show clinical overlap with diseases such as lichen planus and others that may cause desquamative gingivitis. As direct immunofluorescence is expensive, we sought to determine if routine histology alone would be sufficient to distinguish between oral autoimmune bullous disorders and mimics. Methods We searched the records for patients with a suspected oral autoimmune bullous disorder who underwent biopsies for concurrent routine histologic evaluation and direct immunofluorescence and who had at least one follow‐up visit. Cases were separated into high and low suspicion subgroups based on clinical findings. Results Within 148 cases, the sensitivity of routine histology alone was 0.810, with a negative predictive value of 0.889. However, the specificity was 0.989 with a positive predictive value of 0.979. Of the high suspicion cases, 57 (47.1%) were found to be consistent with an oral autoimmune bullous disorder, with a total of 11 histologic false negatives. 8 cases, all in the high suspicion subgroup, showed indeterminate direct immunofluorescence results. There were no histologic false negatives or inconclusive direct immunofluorescence results in the low suspicion subgroup. Conclusions In patients with a low clinical suspicion for an oral autoimmune bullous disorder, it is reasonable and more cost‐effective to evaluate the lesion with routine histology alone.

Type of Medium: Online Resource

ISSN: 1354-523X , 1601-0825

URL: Issue

URL: Article

DOI: 10.1111/odi.v26.1

DOI: 10.1111/odi.13159

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 2008428-6

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Politics, culture, and the legitimacy of disease: the case of Buerger’s disease

Lockwood, Stephen J. ; Bresler, Scott C. ; Granter, Scott R.

Springer Science and Business Media LLC ; 2016

In: Clinical Rheumatology Vol. 35, No. 9 ( 2016-9), p. 2145-2149

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In: Clinical Rheumatology, Springer Science and Business Media LLC, Vol. 35, No. 9 ( 2016-9), p. 2145-2149

Type of Medium: Online Resource

ISSN: 0770-3198 , 1434-9949

URL: Article

DOI: 10.1007/s10067-016-3310-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 1480901-1

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Utility of Direct Immunofluorescence Testing for IgA in Patients With High and Low Clinical Suspicion for Dermatitis Herpetiformis

Bresler, Scott C. ; Granter, Scott R.

Oxford University Press (OUP) ; 2015

In: American Journal of Clinical Pathology Vol. 144, No. 6 ( 2015-12-01), p. 880-884

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In: American Journal of Clinical Pathology, Oxford University Press (OUP), Vol. 144, No. 6 ( 2015-12-01), p. 880-884

Type of Medium: Online Resource

ISSN: 0002-9173 , 1943-7722

URL: Article

DOI: 10.1309/AJCPXIVSR6OZK1HU

RVK:

YV 2000

RVK:

XA 18700

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2015

detail.hit.zdb_id: 2039921-2

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Integrative Genome Comparison of Primary and Metastatic Melanomas

Kabbarah, Omar ; Nogueira, Cristina ; Feng, Bin ; [et al.]

Public Library of Science (PLoS) ; 2010

In: PLoS ONE Vol. 5, No. 5 ( 2010-5-24), p. e10770-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 5, No. 5 ( 2010-5-24), p. e10770-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0010770

DOI: 10.1371/journal.pone.0010770.g001

DOI: 10.1371/journal.pone.0010770.g002

DOI: 10.1371/journal.pone.0010770.g003

DOI: 10.1371/journal.pone.0010770.t001

DOI: 10.1371/journal.pone.0010770.t002

DOI: 10.1371/journal.pone.0010770.s001

DOI: 10.1371/journal.pone.0010770.s002

DOI: 10.1371/journal.pone.0010770.s003

DOI: 10.1371/journal.pone.0010770.s004

DOI: 10.1371/journal.pone.0010770.s005

DOI: 10.1371/journal.pone.0010770.s006

DOI: 10.1371/journal.pone.0010770.s007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2010

detail.hit.zdb_id: 2267670-3

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The Authors’ Reply

Lee, Kenneth R. ; Genest, David R. ; Minter, Lori J. ; [et al.]

Oxford University Press (OUP) ; 1999

In: American Journal of Clinical Pathology Vol. 111, No. 4 ( 1999-04-01), p. 568-569

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In: American Journal of Clinical Pathology, Oxford University Press (OUP), Vol. 111, No. 4 ( 1999-04-01), p. 568-569

Type of Medium: Online Resource

ISSN: 0002-9173 , 1943-7722

URL: Article

DOI: 10.1093/ajcp/111.4.568

RVK:

YV 2000

RVK:

XA 18700

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 1999

detail.hit.zdb_id: 2039921-2

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