In:
Psychosomatic Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 84, No. 2 ( 2022-2), p. 133-140
Abstract:
This study aimed to investigate the role of systemic inflammation in reduced cognitive functioning in patients with early-stage heart failure (HF) while determining associations with other cardiovascular risk factors. Methods Patients with stage B HF ( n = 270; mean [standard deviation] age = 66.1 [10.1] years) were examined cross-sectionally for relationships among cardiovascular disease (CVD) and psychological risk factors, C-reactive protein (CRP), and Montreal Cognitive Assessment (MoCA) scores. A subsample ( n = 83) at high risk for stage C HF (B-type natriuretic peptide levels ≥65 pg/ml) were followed up for 12 months for relationships between CRP levels and cognitive function. Results Baseline smoking ( χ 2 = 6.33), unmarried ( χ 2 = 12.0), hypertension ( χ 2 = 5.72), greater body mass index ( d = 0.45), and physical fatigue ( d = 0.25) were related to higher CRP levels ( p values 〈 .05). Cross-sectionally, CRP levels were negatively related to MoCA scores, beyond CVD (Δ R 2 = 0.022, β = −0.170, p 〈 .010) and psychological risk factors (Δ R 2 = 0.016, β = 0.145, p 〈 .027), and related to mild cognitive impairment criteria (odds ratio = 1.35, 95% confidence interval [CI] = 1.00–1.81, p = .046). Across 12 months, B-type natriuretic peptide high-risk patients with CRP levels ≥3 mg/L had lower MoCA scores (23.6; 95% CI = 22.4–24.8) than did patients with CRP levels 〈 3 mg/L (25.4; 95% CI = 24.4–26.5; p = .024). Conclusions Patients with stage B HF and heightened CRP levels had greater cognitive impairment at baseline and follow-up, independent of CVD and potentially psychological risk factors. Low-grade systemic inflammation may be one mechanism involved in cognitive dysfunction at early stages of HF.
Type of Medium:
Online Resource
ISSN:
1534-7796
,
0033-3174
DOI:
10.1097/PSY.0000000000001033
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
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