In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 195, No. 2 ( 1958-10-31), p. 347-353
Abstract:
Electrolytes were determined on plasma, muscle and urine of Na, K and Cl triple-depleted rats following administration for 5 days of equimolar quantities of various electrolyte solutions (NaCl, NaHCO 3 , KCl, KHCO 3 and NH 4 Cl) with and without Diamox. An attempt was made to relate changes of the plasma HCO 3 concentration to an exchange of H + between extracellular and intracellular fluids and to renal anion and cation excretion. Dietary restriction of Na, K and Cl for 35 days led to a slightly increased plasma HCO 3 . Supplementation with Na salts caused a striking increase in plasma HCO 3 , with KCl a slight fall, with KHCO 3 a slight rise, and with NH 4 Cl a marked decrease. In the majority of experiments the altered plasma HCO 3 could not be predicted from the H + exchange, based on relative changes of muscle Na and K. However, in general, it could be predicted on the basis of the relative changes in plasma Cl and Na, which in turn seem to be related to urinary anion and cation excretion.
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1958.195.2.347
Language:
English
Publisher:
American Physiological Society
Publication Date:
1958
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12
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