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Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abani, O ; Abbas, A ; Abbas, F ; [et al.]

Elsevier BV ; 2023

In: The Lancet Diabetes & Endocrinology Vol. 11, No. 12 ( 2023-12), p. 905-914

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In: The Lancet Diabetes & Endocrinology, Elsevier BV, Vol. 11, No. 12 ( 2023-12), p. 905-914

Type of Medium: Online Resource

ISSN: 2213-8587

URL: Article

DOI: 10.1016/S2213-8587(23)00253-X

Language: English

Publisher: Elsevier BV

Publication Date: 2023

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One-Year Outcomes of Out-of-Hospital Administration of Intravenous Glucose, Insulin, and Potassium (GIK) in Patients With Suspected Acute Coronary Syndromes (from the IMMEDIATE [Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care] Trial)

Selker, Harry P. ; Udelson, James E. ; Massaro, Joseph M. ; [et al.]

Elsevier BV ; 2014

In: The American Journal of Cardiology Vol. 113, No. 10 ( 2014-05), p. 1599-1605

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In: The American Journal of Cardiology, Elsevier BV, Vol. 113, No. 10 ( 2014-05), p. 1599-1605

Type of Medium: Online Resource

ISSN: 0002-9149

URL: Article

DOI: 10.1016/j.amjcard.2014.02.010

RVK:

XA 18500

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 2019595-3

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Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

Faust, Saul N ; Haynes, Richard ; Jones, Christine E ; [et al.]

Elsevier BV ; 2024

In: The Lancet Child & Adolescent Health Vol. 8, No. 3 ( 2024-03), p. 190-200

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In: The Lancet Child & Adolescent Health, Elsevier BV, Vol. 8, No. 3 ( 2024-03), p. 190-200

Type of Medium: Online Resource

ISSN: 2352-4642

URL: Article

DOI: 10.1016/S2352-4642(23)00316-4

Language: English

Publisher: Elsevier BV

Publication Date: 2024

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Genome Modeling System: A Knowledge Management Platform for Genomics

Griffith, Malachi ; Griffith, Obi L. ; Smith, Scott M. ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS Computational Biology Vol. 11, No. 7 ( 2015-7-9), p. e1004274-

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In: PLOS Computational Biology, Public Library of Science (PLoS), Vol. 11, No. 7 ( 2015-7-9), p. e1004274-

Type of Medium: Online Resource

ISSN: 1553-7358

URL: Article

DOI: 10.1371/journal.pcbi.1004274

DOI: 10.1371/journal.pcbi.1004274.g001

DOI: 10.1371/journal.pcbi.1004274.g002

DOI: 10.1371/journal.pcbi.1004274.g003

DOI: 10.1371/journal.pcbi.1004274.g004

DOI: 10.1371/journal.pcbi.1004274.g005

DOI: 10.1371/journal.pcbi.1004274.t001

DOI: 10.1371/journal.pcbi.1004274.t002

DOI: 10.1371/journal.pcbi.1004274.t003

DOI: 10.1371/journal.pcbi.1004274.s001

DOI: 10.1371/journal.pcbi.1004274.s002

DOI: 10.1371/journal.pcbi.1004274.s003

DOI: 10.1371/journal.pcbi.1004274.s004

DOI: 10.1371/journal.pcbi.1004274.s005

DOI: 10.1371/journal.pcbi.1004274.s006

DOI: 10.1371/journal.pcbi.1004274.s007

DOI: 10.1371/journal.pcbi.1004274.s008

DOI: 10.1371/journal.pcbi.1004274.s009

DOI: 10.1371/journal.pcbi.1004274.s010

DOI: 10.1371/journal.pcbi.1004274.s011

DOI: 10.1371/journal.pcbi.1004274.s012

DOI: 10.1371/journal.pcbi.1004274.s013

DOI: 10.1371/journal.pcbi.1004274.s014

DOI: 10.1371/journal.pcbi.1004274.s015

DOI: 10.1371/journal.pcbi.1004274.s016

DOI: 10.1371/journal.pcbi.1004274.s017

DOI: 10.1371/journal.pcbi.1004274.s018

DOI: 10.1371/journal.pcbi.1004274.s019

DOI: 10.1371/journal.pcbi.1004274.s020

DOI: 10.1371/journal.pcbi.1004274.s021

DOI: 10.1371/journal.pcbi.1004274.s022

DOI: 10.1371/journal.pcbi.1004274.s023

DOI: 10.1371/journal.pcbi.1004274.s024

DOI: 10.1371/journal.pcbi.1004274.s025

DOI: 10.1371/journal.pcbi.1004274.s026

DOI: 10.1371/journal.pcbi.1004274.s027

DOI: 10.1371/journal.pcbi.1004274.s028

DOI: 10.1371/journal.pcbi.1004274.s029

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2193340-6

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DGIdb: mining the druggable genome

Griffith, Malachi ; Griffith, Obi L ; Coffman, Adam C ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Nature Methods Vol. 10, No. 12 ( 2013-12), p. 1209-1210

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In: Nature Methods, Springer Science and Business Media LLC, Vol. 10, No. 12 ( 2013-12), p. 1209-1210

Type of Medium: Online Resource

ISSN: 1548-7091 , 1548-7105

URL: Article

DOI: 10.1038/nmeth.2689

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2163081-1

SSG: 12

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Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration

Yu, Jeannette J. ; Agrón, Elvira ; Clemons, Traci E. ; [et al.]

Elsevier BV ; 2019

In: Ophthalmology Vol. 126, No. 2 ( 2019-02), p. 261-273

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In: Ophthalmology, Elsevier BV, Vol. 126, No. 2 ( 2019-02), p. 261-273

Type of Medium: Online Resource

ISSN: 0161-6420

URL: Article

DOI: 10.1016/j.ophtha.2018.08.017

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2019

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Progression of Geographic Atrophy in Age-related Macular Degeneration

Keenan, Tiarnan D. ; Agrón, Elvira ; Domalpally, Amitha ; [et al.]

Elsevier BV ; 2018

In: Ophthalmology Vol. 125, No. 12 ( 2018-12), p. 1913-1928

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In: Ophthalmology, Elsevier BV, Vol. 125, No. 12 ( 2018-12), p. 1913-1928

Type of Medium: Online Resource

ISSN: 0161-6420

URL: Article

DOI: 10.1016/j.ophtha.2018.05.028

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

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CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

Griffith, Malachi ; Spies, Nicholas C ; Krysiak, Kilannin ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Nature Genetics Vol. 49, No. 2 ( 2017-2), p. 170-174

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 49, No. 2 ( 2017-2), p. 170-174

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3774

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 1494946-5

SSG: 12

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Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Geriatric Medicine Research Collaborative ; Alsahab, Mustafa ; Beishon, Lucy ; [et al.]

Oxford University Press (OUP) ; 2021

In: Age and Ageing Vol. 50, No. 3 ( 2021-05-05), p. 617-630

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In: Age and Ageing, Oxford University Press (OUP), Vol. 50, No. 3 ( 2021-05-05), p. 617-630

Abstract: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age ( & gt;80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.

Type of Medium: Online Resource

ISSN: 0002-0729 , 1468-2834

URL: Article

DOI: 10.1093/ageing/afab026

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2065766-3

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Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia

Griffith, Malachi ; Griffith, Obi L. ; Krysiak, Kilannin ; [et al.]

Elsevier BV ; 2016

In: Experimental Hematology Vol. 44, No. 7 ( 2016-07), p. 603-613

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In: Experimental Hematology, Elsevier BV, Vol. 44, No. 7 ( 2016-07), p. 603-613

Type of Medium: Online Resource

ISSN: 0301-472X

URL: Article

DOI: 10.1016/j.exphem.2016.04.011

RVK:

XA 42470

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2005403-8

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