In:
Clinical and Experimental Immunology, Oxford University Press (OUP), Vol. 91, No. 1 ( 2008-06-28), p. 176-182
Abstract:
After 3–4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophagc- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cylometric analysis revealed a rather homogeneous cell population with marked autofluorescence; the large majority of the cells expressed CD14. CD11a,b, and c, Fc receptors for IgG, FcγRI, II, and III, and HLA class II molecules. Interfcron-gamma (IFN-γ). bacteria, and bacterial products modulated expression of some of the surface markers, induced and/ or enhanced respiratory burst, phagoeytic activity, secretion of tumour necrosis factor, and lumouricidal activity; in contrast, these cells were not able to generate reactive nitrogen intermediates.
Type of Medium:
Online Resource
ISSN:
0009-9104
,
1365-2249
DOI:
10.1111/j.1365-2249.1993.tb03375.x
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2008
detail.hit.zdb_id:
2020024-9
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