In:
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley, Vol. 57, No. 7 ( 2014-06-15), p. 441-447
Abstract:
A novel approach towards the synthesis of radiolabeled organometallic rhenium complexes is presented. We successfully synthesized and analyzed the first 188 Re‐labeled N ‐heterocyclic biscarbene complex, trans ‐dioxobis(1,1′‐methylene‐ bis (3,3′‐diisopropylimidazolium‐2‐ylidene)) 188 rhenium(V) hexafluorophosphate ( 188 Re‐4) via transmetalation using an air‐stable and moisture‐stable silver(I) biscarbene complex. In order to assess the viability of this complex as a potential lead structure for in vivo applications, the stability of the 188 Re‐NHC complex was tested in physiologically relevant media. Ultimately, our studies illustrate that the complex we synthesized dissociates rapidly and is therefore unsuitable for use in radiopharmaceuticals. However, it is clear that the transmetalation approach we have developed is a rapid, robust, and mild method for the synthesis of new 188 Re‐labeled carbene complexes. Copyright © 2014 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0362-4803
,
1099-1344
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1491841-9
SSG:
15,3
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