In:
Journal of Porphyrins and Phthalocyanines, World Scientific Pub Co Pte Ltd, Vol. 25, No. 07n08 ( 2021-07), p. 630-638
Abstract:
Acylation of electrophilic strained molecules can be accomplished with N-acyl-glutarimides utilizing the polarity-reversal strategy. In this approach cobalt catalysis enables the generation of nucleophilic radicals via strain release while the Ni-catalyst facilitates the cross-coupling with the acyl derivative. This approach gives acylated cyclobutanes, known bioisosters highly desirable by the pharmaceutical industry.
Type of Medium:
Online Resource
ISSN:
1088-4246
,
1099-1409
DOI:
10.1142/S1088424621500528
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2021
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