In:
Acta Crystallographica Section B Structural Science, International Union of Crystallography (IUCr), Vol. 62, No. 5 ( 2006-10-01), p. 889-896
Abstract:
The human tachykinin NK-2 (hNK-2) receptor is considered a promising target for relevant pathologies at the respiratory, gastrointestinal and genitourinary level. With the aim of reducing the complexity of existing peptide antagonists, two series of hNK-2 receptor antagonists were designed, with the support of modelling, and synthesized. The X-ray structure determination of two compounds, each belonging to one of the two series, allowed the experimental validation of the initial rationale. In addition, it has been found that the two series share a β-turn structure, a key feature for binding the hNK-2 receptor.
Type of Medium:
Online Resource
ISSN:
0108-7681
DOI:
10.1107/S0108768106018167
DOI:
10.1107/S0108768106018167/gp5007sup1.cif
DOI:
10.1107/S0108768106018167/gp50071sup2.hkl
DOI:
10.1107/S0108768106018167/gp50072sup3.hkl
Language:
Unknown
Publisher:
International Union of Crystallography (IUCr)
Publication Date:
2006
detail.hit.zdb_id:
2020841-8
SSG:
13
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