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DNA methylation profiling reveals potential biomarkers of β-lactams induced fatal anaphylactic shock

Guo, Xiangjie ; Bai, Yaqin ; Jia, Xiao ; [et al.]

Elsevier BV ; 2024

In: Forensic Science International Vol. 356 ( 2024-03), p. 111943-

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In: Forensic Science International, Elsevier BV, Vol. 356 ( 2024-03), p. 111943-

Type of Medium: Online Resource

ISSN: 0379-0738

URL: Article

DOI: 10.1016/j.forsciint.2024.111943

RVK:

XA 43770

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2006235-7

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Table_9.csv

Wang, Yifu ; Guo, Bingqian ; Guo, Yajie ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Endocrinology Vol. 13 ( 2022-11-17)

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In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-11-17)

Abstract: Human fetal adrenal glands produce substantial amounts of dehydroepiandrosterone (DHEA), which is one of the most important precursors of sex hormones. However, the underlying biological mechanism remains largely unknown. Herein, we sequenced human fetal adrenal glands and gonads from 7 to 14 gestational weeks (GW) via 10× Genomics single-cell transcriptome techniques, reconstructed their location information by spatial transcriptomics. Relative to gonads, adrenal glands begin to synthesize steroids early. The coordination among steroidogenic cells and multiple non-steroidogenic cells promotes adrenal cortex construction and steroid synthesis. Notably, during the window of sexual differentiation (8–12 GW), key enzyme gene expression shifts to accelerate DHEA synthesis in males and cortisol synthesis in females. Our research highlights the robustness of the action of fetal adrenal glands on gonads to modify the process of sexual differentiation.

Type of Medium: Online Resource

ISSN: 1664-2392

URL: Article

DOI: 10.3389/fendo.2022.1036517

DOI: 10.3389/fendo.2022.1036517.s001

DOI: 10.3389/fendo.2022.1036517.s002

DOI: 10.3389/fendo.2022.1036517.s003

DOI: 10.3389/fendo.2022.1036517.s004

DOI: 10.3389/fendo.2022.1036517.s005

DOI: 10.3389/fendo.2022.1036517.s006

DOI: 10.3389/fendo.2022.1036517.s007

DOI: 10.3389/fendo.2022.1036517.s008

DOI: 10.3389/fendo.2022.1036517.s009

DOI: 10.3389/fendo.2022.1036517.s010

DOI: 10.3389/fendo.2022.1036517.s011

DOI: 10.3389/fendo.2022.1036517.s012

DOI: 10.3389/fendo.2022.1036517.s013

DOI: 10.3389/fendo.2022.1036517.s014

DOI: 10.3389/fendo.2022.1036517.s015

DOI: 10.3389/fendo.2022.1036517.s016

DOI: 10.3389/fendo.2022.1036517.s017

DOI: 10.3389/fendo.2022.1036517.s018

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2592084-4

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Human‐like adrenal features in Chinese tree shrew revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

Jiang, Jinghang ; Guangxi Medical University Center for Genomic and Personalized Medicine ; Wang, Yifu ; [et al.]

Zoological Research ; 2023

In: Zoological Research Vol. 0, No. 0 ( 2023), p. 0-0

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In: Zoological Research, Zoological Research, Vol. 0, No. 0 ( 2023), p. 0-0

Type of Medium: Online Resource

ISSN: 2095-8137

URL: Article

DOI: 10.24272/j.issn.2095-8137.2023.280

Language: English

Publisher: Zoological Research

Publication Date: 2023

detail.hit.zdb_id: 2196960-7

SSG: 12

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Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic

Sun, Tao ; Zhang, Guangping ; Guo, Zhongyuan ; [et al.]

Elsevier BV ; 2020

In: Journal of Controlled Release Vol. 321 ( 2020-05), p. 483-496

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In: Journal of Controlled Release, Elsevier BV, Vol. 321 ( 2020-05), p. 483-496

Type of Medium: Online Resource

ISSN: 0168-3659

URL: Article

DOI: 10.1016/j.jconrel.2020.02.023

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1482453-X

SSG: 15,3

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Forensic toxicokinetics of difenidol hydrochloride in vivo verified by practical lethal cases

Niu, Weifen ; Ren, Tongxi ; Wang, Yandan ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-07-11)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-07-11)

Abstract: A gas chromatography-mass spectrometry (GC–MS) method for the determination of difenidol hydrochloride in biological specimens has been developed. The method exhibited excellent recovery ( 〉 90%) and precision (RSD 〈 10%), and the LOD was 0.05 μg/mL or μg/g, which met the requirements of bioanalytical method. Through the animal model of the forensic toxicokinetics, the dynamic distribution, postmortem redistribution (PMR) and stability in specimen preservation process of difenidol in animals were studied. The experimental results showed that after intragastric administration, the difenidol’s concentrations in the heart-blood and various organs increased over time except stomach, and then decreased gradually after reaching the peaks of concentration. The toxicological kinetics equation and toxicokinetic parameters were established by processing the data of the mean drug concentration of difenidol changing with time. In PMR experiment, the concentrations of difenidol in some organs closer to the gastrointestinal tract (heart-blood, heart, liver, lung, kidney, and spleen) changed significantly at different time points. But the concentration of difenidol in brain tissues which were far away from the gastrointestinal tract and muscles with larger overall mass was relatively stable. PMR of difenidol was therefore confirmed. Thus, the effect of PMR on the concentration of difenidol in the specimens should be considered in cases involving difenidol poisoning or death. Furthermore, the stability of difenidol in heart-blood samples from poisoned rats was investigated at various time points and under different preservation conditions (20 °C, 4 °C, − 20 °C and 20 °C (1% NaF)) for a period of two months. Difenidol was stable and did not decompose in the preserved blood. Therefore, this study provided the experimental basis for the forensic identification of the cases of difenidol hydrochloride poisoning (death). PMR has been verified by practical lethal cases.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-38246-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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Endogenous albumin-mediated delivery of redox-responsive paclitaxel-loaded micelles for targeted cancer therapy

Zhang, Yujie ; Guo, Zhongyuan ; Cao, Zhonglian ; [et al.]

Elsevier BV ; 2018

In: Biomaterials Vol. 183 ( 2018-11), p. 243-257

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In: Biomaterials, Elsevier BV, Vol. 183 ( 2018-11), p. 243-257

Type of Medium: Online Resource

ISSN: 0142-9612

URL: Article

DOI: 10.1016/j.biomaterials.2018.06.002

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2004010-6

SSG: 12

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A covert underwater acoustic communication method based on spread spectrum digital watermarking

Yang, Shaofan ; Guo, Zhongyuan ; Ren, Qunyan ; [et al.]

Acoustical Society of America (ASA) ; 2016

In: Journal of the Acoustical Society of America Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3230-3230

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In: Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3230-3230

Abstract: The covert underwater acoustic communication is necessary under some circumstances when the contents of transmission or location of transmitter are required to be concealed. In this paper, the signal transmitter and the information detector are designed, which hides the spread spectrum digital watermark (SSDW) into the log-spectrum of dolphin whistles that are as a carrier and detects SSDW by matched filtering in the same log-spectrum. Various factors of noise, carrier and multipath in channels may degrade the performance of the method. In order to analyze their effects, corresponding channel models in log-spectrum domain are derived from the additive Gaussian noise channel and the underwater time-varying acoustic multipath channel. Results suggests that the effects of channel noise and the carrier are equivalent to that of two additive Gaussian noise terms attached to the correct decision and the proposed method also has a good multipath extension tolerance performance. Preliminary results obtained form at-sea experiments showed that the data rate can achieve 6 bps and bit error rate (BER) under 10-3 in the distance of 5 km.

Type of Medium: Online Resource

ISSN: 0001-4966 , 1520-8524

URL: Article

DOI: 10.1121/1.4970211

RVK:

EQ 1000

Language: English

Publisher: Acoustical Society of America (ASA)

Publication Date: 2016

detail.hit.zdb_id: 1461063-2

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Ethyl methanesulfonate mutant library construction in Gossypium hirsutum L. for allotetraploid functional genomics and germplasm innovation

Lian, Xin ; Liu, Yan ; Guo, Huihui ; [et al.]

Wiley ; 2020

In: The Plant Journal Vol. 103, No. 2 ( 2020-07), p. 858-868

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In: The Plant Journal, Wiley, Vol. 103, No. 2 ( 2020-07), p. 858-868

Abstract: This study established and verified efficient method/procedure suitable for EMS‐based mutant library construction as the general reference guide in allotetraploid upland cotton. HRM examination and genome‐wide mutation analyses demonstrated ideal quality of the library with appropriate high mutation density and saturated genome. The abundant library is composed of a broad repertoire of mutants as the valuable new resource for basic genetic research and functional genomics underlying complex allotetraploid traits, as well as cotton breeding.

Type of Medium: Online Resource

ISSN: 0960-7412 , 1365-313X

URL: Issue

URL: Article

DOI: 10.1111/tpj.v103.2

DOI: 10.1111/tpj.14755

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 2020961-7

SSG: 12

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Arbuscular mycorrhizal fungi (AMF) enhanced the growth, yield, fiber quality and phosphorus regulation in upland cotton (Gossypium hirsutum L.)

Gao, Xinpeng ; Guo, Huihui ; Zhang, Qiang ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Scientific Reports Vol. 10, No. 1 ( 2020-02-07)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-02-07)

Abstract: We previously reported on the strong symbiosis of AMF species ( Rhizophagus irregularis CD1) with the cotton ( Gossypium hirsutum L.) which is grown worldwide. In current study, it was thus investigated in farmland to determine the biological control effect of AMF on phosphorus acquisition and related gene expression regulation, plant growth and development, and a series of agronomic traits associated with yield and fiber quality in cotton. When AMF and cotton were symbiotic, the expression of the specific phosphate transporter family genes and P concentration in the cotton biomass were significantly enhanced. The photosynthesis, growth, boll number per plant and the maturity of the fiber were increased through the symbiosis between cotton and AMF. Statistical analysis showed a highly significant increase in yield for inoculated plots compared with that from the non inoculated controls, with an increase percentage of 28.54%. These findings clearly demonstrate here the benefits of AMF-based inoculation on phosphorus acquisition, growth, seed cotton yield and fiber quality in cotton. Further improvement of these beneficial inoculants on crops will help increase farmers’ income all over the world both now and in the future.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-020-59180-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2615211-3

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Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

Lu, Yifei ; Guo, Zhongyuan ; Zhang, Yujie ; [et al.]

Wiley ; 2019

In: Advanced Science Vol. 6, No. 4 ( 2019-02)

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In: Advanced Science, Wiley, Vol. 6, No. 4 ( 2019-02)

Type of Medium: Online Resource

ISSN: 2198-3844 , 2198-3844

URL: Issue

URL: Article

DOI: 10.1002/advs.v6.4

DOI: 10.1002/advs.201970024

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2808093-2

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