In:
Anaesthesia, Wiley, Vol. 41, No. 6 ( 1986-06), p. 579-581
Abstract:
The effect of anaesthesia and surgery on microsomal enzyme activity was studied in 19 children aged 4–9 years, scheduled for tonsillectomy. The children were randomly allocated to either halothane or ketamine anaesthesia. Antipyrine clearance was measured before and 4 days after surgery by u salivary one–sample technique. Statistically signijcant (p 〈 0.001) increases in antipyrine clearance was found in children who received halothane anaesthesia. The antipyrine clearance was increased by a mean of 26% 4 days after surgery, compared with a pre–operative control measurement. No significant change in antipyrine clearance was observed in children who received ketamine anaesthesia. There was also a significant difference in antipyrine clearance changes after surgery between the two groups (p 〈 0.05). Halothane has enzyme–inducing properties after a siigle exposure in children, while a single dose of ketamine does not.
Type of Medium:
Online Resource
ISSN:
0003-2409
,
1365-2044
DOI:
10.1111/ana.1986.41.issue-6
DOI:
10.1111/j.1365-2044.1986.tb13046.x
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
2003379-5
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