X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    The Occurrence of Multiple Sclerosis in the Hutterites of North America
    Cambridge University Press (CUP) ; 1996
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 23, No. 4 ( 1996-11), p. 291-295
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 23, No. 4 ( 1996-11), p. 291-295
    Abstract: Objective : To report the occurrence, clinical characteristics and genealogical analysis of multiple sclerosis in the Hutterites of North-Western United States and Western Canada. Background : The incidence of multiple sclerosis is reported to be lower or rare in certain ethnic groups and genetic isolates and was previously observed to be absent in the Hutterite population. Methods : After long-term surveillance, six patients were identified and clinical examinations and laboratory investigations including VER and MRI were completed. Results : The six cases included two brothers, two first cousins, male and female, another male and female, all representing two of the three endogamous groups of Hutterites, are linked to two common ancestors through lines of descent dating to 1723. The individual pedigrees were analyzed from extensive genealogical records covering eight generations. Conclusion : The incidence of multiple sclerosis in Hutterites is low in a high risk area of North America. A specific mode of inheritance pattern has not been established and a common founder effect may play a role in the development of multiple sclerosis. The genetic contribution of the Hutterites seems greater than previously recognized.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100038245
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1996
    detail.hit.zdb_id: 2577275-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 2
    Online Resource
    Online Resource
    Severe Traumatic Brain Injury in a Large Canadian Health Region
    Cambridge University Press (CUP) ; 2005
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 32, No. 1 ( 2005-02), p. 87-92
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 32, No. 1 ( 2005-02), p. 87-92
    Abstract: Bien que les lésions cérébrales sévères (LCS) causées par un traumatisme crânien aient des conséquences dévastatrices et un impact important en santé publique, l’épidémiologie de cette affection n’a jamais été décrite au Canada. Le but de cette étude est de déterminer l’incidence, les facteurs de risque et l’issue des patients atteints de lésions cérébrales traumatiques graves dans un grand territoire canadien. Méthodes: Une étude de cohorte a été utilisée pour identifier tous les résidents de la région sanitaire de Calgary qui ont été victimes d’un traumatisme dont le score de sévérité des lésions était de 12 ou plus. Les cas inclus dans la cohorte étaient ensuite sélectionnés selon une définition spécifique des LCS Résultats: L’incidence annuelle des LCS était de 11,4 par 100,000 de population. Elle était légèrement plus élevée pour les hommes, soit 17,1 par rapport à 5,9 pour les femmes et leur risque relatif était de 2,91 (IC 2,17 à 3,94; p 〈 0,0001). Chez les sujets de plus de 74 ans, on a observé une incidence élevée de traumatismes crâniens. Le risque relatif était de 19,78 (IC 6,27 à 62,3; p 〈 0,0001) dans le groupe ayant le niveau de risque le plus élevé, soit les hommes âgés ( 〉 85 ans) comparé à celui des femmes ayant le risque le plus faible (50 à 64 ans). Cent huit patients sont morts pendant l’hospitalisation, soit un taux de mortalité annuelle de 5,1 par 100,000. Conclusions: Les lésions cérébrales par traumatisme crânien sévère sont fréquentes parmi les résidents de la région sanitaire de Calgary et sont associées à une mortalité élevée. Les hommes et les personnes âgées sont les groupes les plus à risque et constituent des groupes cibles pour les interventions à visée préventive.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100016930
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2005
    detail.hit.zdb_id: 2577275-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 3
    Online Resource
    Online Resource
    Development and validation of the Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19)
    Wiley ; 2020
    In:  Epilepsia Vol. 61, No. 12 ( 2020-12), p. 2729-2738
    Details
    In: Epilepsia, Wiley, Vol. 61, No. 12 ( 2020-12), p. 2729-2738
    Abstract: No validated tools exist to assess satisfaction with epilepsy surgery. We aimed to develop and validate a new measure of patient satisfaction with epilepsy surgery, the 19‐item Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19). Methods An initial 31‐item measure was developed based on literature review, patient focus groups, thematic analysis, and Delphi panels. The questionnaire was administered twice, 4‐6 weeks apart, to 229 adults (≥18 years old) who underwent epilepsy surgery ≥1 year earlier, at three centers in Canada and one in Sweden. Participants also completed seven validated questionnaires to assess construct validity. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) assessed the factorial structure of the questionnaire. Cronbach alpha and intraclass correlation coefficients (ICCs) assessed the internal consistency and test‐retest reliability of the ESSQ‐19. Spearman and polyserial correlations assessed construct validity. Results Median age of participants and time since surgery were 42 years (interquartile range [IQR] = 32‐54) and 5 years (IQR = 2‐8.75), respectively. EFA and CFA yielded 18 items that segregated into four domains (mean score [SD] ), namely, seizure control (76.4 [25]), psychosocial functioning (67.3 [26] ), surgical complications (84 [22]), and recovery from surgery (73 [24] ), one global satisfaction item, and a summary global score (74 [21]). The domain and summary scores demonstrated good to excellent internal reliability (Cronbach ⍺ range = .84‐.95) and test‐retest reliability (ICC range = 0.71‐0.85). Construct validity was supported by predicted correlations with other instruments. Significance The ESSQ‐19 is a new, valid, and reliable measure of patient satisfaction with epilepsy surgery that can be used in clinical and research settings.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v61.12
    DOI: 10.1111/epi.16709
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2002194-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 4
    Online Resource
    Online Resource
    Validity and reliability of global ratings of satisfaction with epilepsy surgery
    Wiley ; 2022
    In:  Epilepsia Vol. 63, No. 4 ( 2022-04), p. 777-788
    Details
    In: Epilepsia, Wiley, Vol. 63, No. 4 ( 2022-04), p. 777-788
    Abstract: We aimed to assess the reliability and validity of single‐item global ratings (GR) of satisfaction with epilepsy surgery. Methods We recruited 240 patients from four centers in Canada and Sweden who underwent epilepsy surgery ≥1 year earlier. Participants completed a validated questionnaire on satisfaction with epilepsy surgery (the ESSQ‐19), plus a single‐item GR of satisfaction with epilepsy surgery twice, 4–6 weeks apart. They also completed validated questionnaires on quality of life, depression, health state utilities, epilepsy severity and disability, medical treatment satisfaction and social desirability. Test‐retest reliability of the GR was assessed with the intra‐class correlation coefficient (ICC). Construct and criterion validity were examined with polyserial correlations between the GR measure of satisfaction and validated questionnaires and with the ESSQ‐19 summary score. Non‐parametric rank tests evaluated levels of satisfaction, and ROC analysis assessed the ability of GRs to distinguish among clinically different patient groups. Results Median age and time since surgery were 42 years (IQR 32–54) and 5 years (IQR 2–8), respectively. The GR demonstrated good to excellent test‐retest reliability (ICC = 0.76; 95% CI 0.67–0.84) and criterion validity (0.85; 95% CI 0.81–0.89), and moderate correlations in the expected direction with instruments assessing quality of life (0.59; 95% CI 0.51–0.63), health utilities (0.55; 95% CI 0.45–0.65), disability (−0.51; 95% CI −0.41, −0.61), depression (−0.48; 95% CI −0.38, −0.58), and epilepsy severity (−0.48; 95% CI −0.38, −0.58). As expected, correlations were lower for social desirability (0.40; 95% CI 0.28–0.52) and medical treatment satisfaction (0.33; 95% CI 0.21–0.45). The GR distinguished participants who were seizure‐free (AUC 0.75; 95% CI 0.67–0.82), depressed (AUC 0.75; 95% CI 0.67–0.83), and self‐rated as having more severe epilepsy (AUC 0.78; 95% CI 0.71–0.85) and being more disabled (AUC 0.82; 95% CI 0.74–0.90). Significance The GR of epilepsy surgery satisfaction showed good measurement properties, distinguished among clinically different patient groups, and appears well‐suited for use in clinical practice and research.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v63.4
    DOI: 10.1111/epi.17184
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2002194-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 5
    Online Resource
    Online Resource
    Epilepsy surgery with intraoperative MRI at 1.5 T
    Elsevier BV ; 2005
    In:  Neurosurgery Clinics of North America Vol. 16, No. 1 ( 2005-1), p. 173-183
    Details
    In: Neurosurgery Clinics of North America, Elsevier BV, Vol. 16, No. 1 ( 2005-1), p. 173-183
    Type of Medium: Online Resource
    ISSN: 1042-3680
    URL: Article
    DOI: 10.1016/j.nec.2004.07.006
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 6
    Online Resource
    Online Resource
    Endoscopic third ventriculostomy to treat hydrocephalus associated with macrocephaly-cutis marmorata telangiectatica congenita : Report of 2 cases
    Journal of Neurosurgery Publishing Group (JNSPG) ; 2009
    In:  Journal of Neurosurgery: Pediatrics Vol. 4, No. 4 ( 2009-10), p. 397-401
    Details
    In: Journal of Neurosurgery: Pediatrics, Journal of Neurosurgery Publishing Group (JNSPG), Vol. 4, No. 4 ( 2009-10), p. 397-401
    Abstract: Macrocephaly-cutis marmorata telangiectatica congenita is a rare overgrowth syndrome commonly associated with hydrocephalus. Although the pathophysiological characteristics of the hydrocephalus in this syndrome is not fully known, previous reports have described its treatment with ventriculoperitoneal shunt placement. The authors describe 2 cases of macrocephaly-cutis marmorata telangiectatica congenita successfully treated for progressive hydrocephalus with endoscopic third ventriculostomy. Both patients experienced clinical and radiographic stabilization following treatment, and these findings offer insight into the pathophysiology of the hydrocephalus and its ideal management.
    Type of Medium: Online Resource
    ISSN: 1933-0707 , 1933-0715
    URL: Article
    DOI: 10.3171/2008.12.PEDS088
    RVK:
    XA 55270.2
    Language: Unknown
    Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
    Publication Date: 2009
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 7
    Online Resource
    Online Resource
    Predicting postoperative epilepsy surgery satisfaction in adults using the 19‐item Epilepsy Surgery Satisfaction Questionnaire and machine learning
    Wiley ; 2021
    In:  Epilepsia Vol. 62, No. 9 ( 2021-09), p. 2103-2112
    Details
    In: Epilepsia, Wiley, Vol. 62, No. 9 ( 2021-09), p. 2103-2112
    Abstract: The 19‐item Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19) is a validated and reliable post hoc means of assessing patient satisfaction with epilepsy surgery. Prediction models building on these data can be used to counsel patients. Methods The ESSQ‐19 was derived and validated on 229 patients recruited from Canada and Sweden. We isolated 201 (88%) patients with complete clinical data for this analysis. These patients were adults (≥18 years old) who underwent epilepsy surgery 1 year or more prior to answering the questionnaire. We extracted each patient’s ESSQ‐19 score (scale is 0–100; 100 represents complete satisfaction) and relevant clinical variables that were standardized prior to the analysis. We used machine learning (linear kernel support vector regression [SVR]) to predict satisfaction and assessed performance using the R 2 calculated following threefold cross‐validation. Model parameters were ranked to infer the importance of each clinical variable to overall satisfaction with epilepsy surgery. Results Median age was 41 years (interquartile range [IQR] = 32–53), and 116 (57%) were female. Median ESSQ‐19 global score was 68 (IQR = 59–75), and median time from surgery was 5.4 years (IQR = 2.0–8.9). Linear kernel SVR performed well following threefold cross‐validation, with an R 2 of .44 (95% confidence interval = .36–.52). Increasing satisfaction was associated with postoperative self‐perceived quality of life, seizure freedom, and reductions in antiseizure medications. Self‐perceived epilepsy disability, age, and increasing frequency of seizures that impair awareness were associated with reduced satisfaction. Significance Machine learning applied postoperatively to the ESSQ‐19 can be used to predict surgical satisfaction. This algorithm, once externally validated, can be used in clinical settings by fixing immutable clinical characteristics and adjusting hypothesized postoperative variables, to counsel patients at an individual level on how satisfied they will be with differing surgical outcomes.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v62.9
    DOI: 10.1111/epi.16992
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2002194-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 8
    Online Resource
    Online Resource
    Intramedullary Spinal Teratoma and Diastematomyelia
    S. Karger AG ; 1999
    In:  Pediatric Neurosurgery Vol. 30, No. 3 ( 1999), p. 140-145
    Details
    In: Pediatric Neurosurgery, S. Karger AG, Vol. 30, No. 3 ( 1999), p. 140-145
    Abstract: The authors present a patient with diastematomyelia and a spinal intramedullary teratoma, remote from the split cord malformation. A split cord malformation at the L 〈 sub 〉 2 〈 /sub 〉 –L 〈 sub 〉 3 〈 /sub 〉 level was initially discovered during investigations for thoracic congenital scoliosis, and this was treated surgically. The teratoma, which was at the level of the scoliosis, went undiagnosed until neurological deterioration occurred many years later. Surgical removal of the teratoma resulted in return to normal function. The potential for coexisting congenital anomalies at separate levels of the spinal cord must be considered in radiological investigations of a developmental spinal lesion.
    Type of Medium: Online Resource
    ISSN: 1016-2291 , 1423-0305
    URL: Article
    DOI: 10.1159/000028782
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1999
    detail.hit.zdb_id: 1483546-0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 9
    Online Resource
    Online Resource
    Neuropsychological Outcome after Endoscopic Third Ventriculostomy
    Cambridge University Press (CUP) ; 2014
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 41, No. 6 ( 2014-11), p. 729-734
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 41, No. 6 ( 2014-11), p. 729-734
    Abstract: Issue neuropsychologique après ventriculostomie endoscopique du troisième ventricule. Contexte: La dysfonction cognitive est une complication fréquente de l’hydrocéphalie obstructive. Le but de cette étude était d’examiner les conséquences de la ventriculostomie endoscopique du troisième ventricule (VETV) sur l’issue neuropsychologique chez des patients présentant un déclin cognitif et une hydrocéphalie obstructive. Méthode: Nous avons effectué une revue rétrospective des dossiers de patients qui ont subi une VETV à l’Université de Calgary et chez qui des tests neuropsychologiques pré et postopératoires avaient été effectués. Les manifestations cliniques au moment de la consultation initiale, l’étiologie de l’hydrocéphalie et la taille du ventricule évaluée au moyen du ratio cornes frontale/occipitale ont été recueillies ainsi que l’issue et les complications de la VETV. De plus, des mesures détaillées de l’intelligence, de l’attention et de la concentration, de la fonction exécutive, de la mémoire visuelle et verbale, des fonctions langagières et de la motricité fine avaient été effectuées. Le changement après traitement a été évalué au moyen de l’Indice de changement fiable ( Reliable Change Index ). Résultats: Treize patients ont été identifiés. L’hydrocéphalie était due à une sténose de l’aqueduc de Sylvius chez 8 patients et à un gliome de la lame tectale du mésencéphale chez 4 patients. La majorité des patients, soit 11 patients sur 13 (85%), présentaient une dysfonction cognitive limite (ÉT ≤ 1) ou un déficit (ÉT ≤ 1,5) dans au moins un domaine. Neuf patients (69%) présentaient une nette amélioration dans au moins un domaine cognitif. Nous avons constaté le plus grand niveau d’amélioration dans le domaine de la mémoire visuelle (42%). Entre le quart et le tiers des patients présentaient une amélioration des tests de quotient intellectuel, de mémoire verbale, d’attention et de concentration et de fonction exécutive. La fonction exécutive s’était détériorée chez deux patients alors que la taille du ventricule s’était améliorée chez 8 patients. Conclusions: La VETV est une intervention sûre et efficace, qui peut donner lieu à des améliorations notables de la dysfonction cognitive associée à l’hydrocéphalie. Les patients qui ne présentent que des troubles cognitifs peuvent tirer bénéfice de la VETV.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/cjn.2014.108
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2014
    detail.hit.zdb_id: 2577275-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
  • 10
    Online Resource
    Online Resource
    The Concurrence of Multiple Sclerosis and Amyotrophic Lateral Sclerosis
    Cambridge University Press (CUP) ; 1986
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 13, No. 1 ( 1986-02), p. 66-69
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 13, No. 1 ( 1986-02), p. 66-69
    Abstract: We report the clinical and pathological findings of the unusual combination of two idiopathic central nervous system diseases, multiple sclerosis and amyotrophic lateral sclerosis in a 56 year old physician with a twenty-seven year history of a disease initially characterized by relapses and remissions, followed by an eight year quiescent period. During the last year of life there was rapid deterioration with development of generalized weakness, atrophy, weight loss and fasciculations of body and tongue, and associated difficulty with swallowing and sudden respiratory failure. The autopsy confirmed characteristic “burned out” plaques of multiple sclerosis and anterior horn cell and axonal degeneration of amyotrophic lateral sclerosis.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100035824
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1986
    detail.hit.zdb_id: 2577275-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    Availability (electronic / print)
Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages