In:
Head & Neck, Wiley, Vol. 38, No. S1 ( 2016-04)
Abstract:
The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease‐free survival (DFS)/locoregional recurrence‐free survival (LRFS), and distant metastases‐free survival (DMFS) in patients with high‐risk primary salivary gland carcinoma who underwent surgery and postoperative (chemo)radiotherapy with curative intention. Methods We reviewed data of 63 patients with high‐risk primary salivary gland carcinoma in a retrospective single‐center audit. Results At a median follow‐up of 31 months (range, 5–145 months), cumulative OS and DFS were 91.7%, 77.6%, and 62.9%, and 82.1%, 65.6%, and 57.7%, respectively, after 1, 2, and 5 years. LRFS and DMFS were 92%, 86%, and 86%, and 83.4%, 70.4%, and 62.3% after 1, 2, and 5 years, respectively. Of all patient‐related, tumor‐related, and treatment‐related factors, high‐grade histology (G3) was the only factor in univariate and multivariate analysis that was predictive for a shorter DMFS (low/intermediate vs high‐grade: 100%, 100%, and 89.4% vs 72.9%, 54.3%, and 42.8% after 1, 2, and 5 years, respectively) and a shorter DFS (low/intermediate vs high‐grade: 100%, 90%, and 84.4% vs 71.2%, 50.1%, and 39.4% after 1, 2, and 5 years, respectively) and OS (low/intermediate vs high‐grade: 100%, 100%, and 86.5% vs 86.5%, 63.2%, and 46.5% after 1, 2, and 5 years, respectively). Conclusion High‐grade tumor histology is a highly significant predictor of a shorter DMFS, OS, and DFS in salivary gland carcinoma, irrespective of histological subtype. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E2041–E2048, 2016
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2001440-5
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