In:
The Laryngoscope, Wiley, Vol. 125, No. 8 ( 2015-08), p. 1861-1868
Abstract:
Follow‐up of patients with oral cavity squamous cell carcinoma (OCSCC) after tumor resection and reconstruction with tissue transfer is challenging. We compared contrast‐enhanced computed tomography (ceCT), 18 F‐fluorodeoxyglucose‐positron emission tomography combined with noncontrast enhanced CT ( 18 F‐FDG‐PET/CT), and 18 F‐FDG‐PET combined with ceCT ( 18 F‐FDG‐PET/ceCT) to determine the accuracy for detection of residual/recurrent disease after flap reconstruction for OCSCC. Study Design and Methods Two readers (R1, R2) retrospectively reviewed a total of 27 18 F‐FDG‐PET/ceCT scans in patients after resection of stage II to IV OCSCC. They recorded the presence of local persistence/recurrence (LR), lymph node metastasis, or distant metastasis independently for ceCT, 18 F‐FDG‐PET/CT, and 18 F‐FDG‐PET/ceCT. Histological workup, imaging follow‐up, or clinical follow‐up served as the standard of reference. Maximum standardized uptake value (SUV max) was evaluated to discriminate between physiological uptake and LR. Results The highest accuracy to detect LR was achieved with 18 F‐FDG‐PET/ceCT, with a sensitivity/specificity of 88%/89% and 88%/79% for R1 and R2, respectively, as compared to ceCT with 75%/79% for R1 and 88%/68% for R2 and 18 F‐FDG‐PET/CT with 88%/58% for both R1 and R2. Receiver‐operating‐characteristic analysis determined a cutoff value for SUV max of 7.2, yielding a sensitivity and specificity of 75% and 94%, respectively, to distinguish LR from physiological 18 F‐FDG uptake. Conclusion 18 F‐FDG‐PET/ceCT seems to be the most reliable tool for locoregional surveillance of OCSCC patients after resection and reconstruction. Level of Evidence 4. Laryngoscope , 125:1861–1868, 2015
Type of Medium:
Online Resource
ISSN:
0023-852X
,
1531-4995
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2026089-1
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