In:
Antiviral Chemistry and Chemotherapy, SAGE Publications, Vol. 30 ( 2022-01), p. 204020662210900-
Abstract:
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na 2 WO 4 × 2H 2 O and Aluminum sulfate octadecahydrate-Al 2 (SO 4 ) 3 × 18H 2 O that we have conditionally named ‘Vomifal’ has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed ‘Vomifal’ has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage – main antiviral properties probably associated with an interferonogenic effect.
Type of Medium:
Online Resource
ISSN:
0956-3202
,
2040-2066
DOI:
10.1177/20402066221090061
Language:
English
Publisher:
SAGE Publications
Publication Date:
2022
detail.hit.zdb_id:
2130088-4
SSG:
15,3
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