In:
European Journal of Haematology, Wiley, Vol. 95, No. 6 ( 2015-12), p. 507-513
Abstract:
As hepcidin‐25 is considered as a key regulator of human iron homoeostasis, this study aimed to compare this parameter with conventional biomarkers and diagnostic tools of iron deficiency ( ID ). Methods In total, 233 hospitalised adult patients, who underwent routine blood testing for ID , were included. All subjects were investigated for hepcidin‐25, reticulocyte haemoglobin content ( CH r), soluble transferrin receptor (sTfR)/log ferritin ratio (i.e. Thomas plot), sTfR, ferritin, transferrin saturation ( TSAT ), C‐reactive protein ( CRP ) and for complete blood cell count. Functional ID was defined as a CH r 〈 28 pg. Separate logistic regression models were calculated with all potential biomarkers to evaluate and compare the predictive performance with respect to functional ID in patients without ( CRP ≤ 0.5 mg/dL) and with ( CRP 〉 0.5 mg/dL) acute‐phase reaction, respectively. Results One hundred seventeen patients with CRP 〉 0.5 mg/dL showed a distinctly higher hepcidin‐25 median value [35.60 (range: 4.27–80.03) ng/mL] as compared to 116 patients with CRP ≤ 0.5 mg/dL [18.55 (range: 3.77–73.01) ng/mL]. With respect to functional ID , sTfR/log ferritin ratio and sTfR were of better positive predictive value ( PPV ) (sTfR/log ferritin ratio: 58.33% and 70.83%; sTfR: 60.00% and 60.00%) than when compared to hepcidin‐25 ( PPV : 37.74% and 42.86%) and ferritin ( PPV : 27.54% and 46.15%) in both subgroups. Conclusions The sTfR/log ferritin ratio, as well as sTfR, were better predictors of functional ID in patients with and without acute‐phase reaction as compared to hepcidin‐25 and ferritin.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2015.95.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2027114-1
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