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The preparation, characterization, structure and dissolution analysis of apremilast solvatomorphs

Wu, Yun-Deng ; Zhang, Xiao-Lei ; Liu, Xiao-Hong ; [et al.]

International Union of Crystallography (IUCr) ; 2017

In: Acta Crystallographica Section C Structural Chemistry Vol. 73, No. 4 ( 2017-04-01), p. 305-313

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In: Acta Crystallographica Section C Structural Chemistry, International Union of Crystallography (IUCr), Vol. 73, No. 4 ( 2017-04-01), p. 305-313

Abstract: Apremilast (AP) {systematic name: ( S )-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4-acetamidoisoindoline-1,3-dione} is an inhibitor of phosphodieasterase-4 (PDE4) and is indicated for the treatment of adult patients with active psoriatic arthritis. The ability of AP to form solvates has been investigated and three so lvatomorphs of AP, namely, the AP ethyl acetate hemisolvate, C 22 H 24 N 2 O 7 S·0.5C 4 H 8 O 2 , the AP toluene hemisolvate, C 22 H 24 N 2 O 7 S·0.5C 7 H 8 , and the AP dichloromethane monosolvate, C 22 H 24 N 2 O 7 S·CH 2 Cl 2 , were obtained. The three AP solvatomorphs were characterized by X-ray powder diffraction, thermogravimetric analysis and differential scanning calorimetry. Single-crystal X-ray diffraction was used to analyze the structures, crystal symmetry, packing modes, stoichiometry and hydrogen-bonding interactions of the solvatomorphs. In addition, dissolution analyses were performed to study the dissolution rates of different AP solvatomorph tablets in vitro and to make comparisons with commercial apremilast tablets (produced by Celgene); all three solvatomorphs showed similar dissolution rates and similar values of the similarity factor f 2 in a comparison of their dissolution profiles.

Type of Medium: Online Resource

ISSN: 2053-2296

URL: Article

DOI: 10.1107/S2053229617002984

DOI: 10.1107/S2053229617002984/fm3048sup1.cif

DOI: 10.1107/S2053229617002984/fm30481sup5.hkl

DOI: 10.1107/S2053229617002984/fm30481sup2.cml

DOI: 10.1107/S2053229617002984/fm30482sup3.cml

DOI: 10.1107/S2053229617002984/fm30483sup4.cml

DOI: 10.1107/S2053229617002984/fm30482sup6.hkl

DOI: 10.1107/S2053229617002984/fm30483sup7.hkl

Language: Unknown

Publisher: International Union of Crystallography (IUCr)

Publication Date: 2017

detail.hit.zdb_id: 2025703-X

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, Daniel J ; Abdelmohsen, Kotb ; Abe, Akihisa ; [et al.]

Informa UK Limited ; 2016

In: Autophagy Vol. 12, No. 1 ( 2016-01-02), p. 1-222

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In: Autophagy, Informa UK Limited, Vol. 12, No. 1 ( 2016-01-02), p. 1-222

Type of Medium: Online Resource

ISSN: 1554-8627 , 1554-8635

URL: Article

DOI: 10.1080/15548627.2015.1100356

Language: English

Publisher: Informa UK Limited

Publication Date: 2016

detail.hit.zdb_id: 2262043-6

SSG: 12

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, Daniel J. ; Abdel-Aziz, Amal Kamal ; Abdelfatah, Sara ; [et al.]

Informa UK Limited ; 2021

In: Autophagy Vol. 17, No. 1 ( 2021-01-02), p. 1-382

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In: Autophagy, Informa UK Limited, Vol. 17, No. 1 ( 2021-01-02), p. 1-382

Type of Medium: Online Resource

ISSN: 1554-8627 , 1554-8635

URL: Article

DOI: 10.1080/15548627.2020.1797280

Language: English

Publisher: Informa UK Limited

Publication Date: 2021

detail.hit.zdb_id: 2262043-6

SSG: 12

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World Congress Integrative Medicine & Health 2017: part two : Berlin, Germany. 3–5 May 2017

Ee, Carolyn ; Thuraisingam, Sharmala ; Pirotta, Marie ; [et al.]

Springer Science and Business Media LLC ; 2017

In: BMC Complementary and Alternative Medicine Vol. 17, No. S1 ( 2017-6)

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In: BMC Complementary and Alternative Medicine, Springer Science and Business Media LLC, Vol. 17, No. S1 ( 2017-6)

Type of Medium: Online Resource

ISSN: 1472-6882

URL: Article

DOI: 10.1186/s12906-017-1783-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2050429-9

detail.hit.zdb_id: 3037610-5

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Guidelines for the diagnosis and treatment of neurally mediated syncope in children and adolescents (revised 2024)

Wang, Cheng ; Liao, Ying ; Wang, Shuo ; [et al.]

Springer Science and Business Media LLC ; 2024

In: World Journal of Pediatrics Vol. 20, No. 10 ( 2024-10), p. 983-1002

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In: World Journal of Pediatrics, Springer Science and Business Media LLC, Vol. 20, No. 10 ( 2024-10), p. 983-1002

Abstract: Significant progress has been made in the diagnosis and treatment of pediatric syncope since the publication of the “2018 Chinese Pediatric Cardiology Society (CPCS) guideline for diagnosis and treatment of syncope in children and adolescents” (“2018 Edition Guidelines”). Therefore, we have revised and updated it to assist pediatricians in effectively managing children with syncope. Data sources According to the “2018 Edition Guidelines”, the expert groups collected clinical evidence, evaluated preliminary recommendations, and then organized open-ended discussions to form the recommendations. This guideline was developed by reviewing the literature and studies in databases including PubMed, Cochrane, EMBASE, China Biomedical Database, and Chinese Journal Full-text Database up to April 2024. Search terms included “syncope”, “children”, “adolescents”, “diagnosis”, and “treatment.” Results The guidelines were based on the latest global research progress and were evidence-based. The classification of syncope etiology, diagnostic procedures, postural tests, such as the active standing test, head-up tilt test, and active sitting test, clinical diagnosis, and individualized treatment for neurally mediated syncope in pediatric population were included. Conclusions The guidelines were updated based on the latest literature. The concepts of sitting tachycardia syndrome and sitting hypertension were introduced and the comorbidities of neurally mediated syncope were emphasized. Some biomarkers used for individualized treatment were underlined. Specific suggestions were put forward for non-pharmacological therapies as well as the follow-up process. The new guidelines will provide comprehensive guidance and reference for the diagnosis and treatment of neurally mediated syncope in children and adolescents.

Type of Medium: Online Resource

ISSN: 1708-8569 , 1867-0687

URL: Article

DOI: 10.1007/s12519-024-00819-w

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2024

detail.hit.zdb_id: 2445122-8

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Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients

Wang, I.-Kuan ; Liu, Chung-Hsiang ; Yen, Tzung-Hai ; [et al.]

Elsevier BV ; 2017

In: Journal of Stroke and Cerebrovascular Diseases Vol. 26, No. 6 ( 2017-06), p. 1349-1356

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In: Journal of Stroke and Cerebrovascular Diseases, Elsevier BV, Vol. 26, No. 6 ( 2017-06), p. 1349-1356

Type of Medium: Online Resource

ISSN: 1052-3057

URL: Article

DOI: 10.1016/j.jstrokecerebrovasdis.2017.02.007

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2052957-0

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Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial

Holman, Rury R ; Coleman, Ruth L ; Chan, Juliana C N ; [et al.]

Elsevier BV ; 2017

In: The Lancet Diabetes & Endocrinology Vol. 5, No. 11 ( 2017-11), p. 877-886

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In: The Lancet Diabetes & Endocrinology, Elsevier BV, Vol. 5, No. 11 ( 2017-11), p. 877-886

Type of Medium: Online Resource

ISSN: 2213-8587

URL: Article

DOI: 10.1016/S2213-8587(17)30309-1

Language: English

Publisher: Elsevier BV

Publication Date: 2017

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The first data release (DR1) of the LAMOST regular survey

Luo, A-Li ; Zhao, Yong-Heng ; Zhao, Gang ; [et al.]

IOP Publishing ; 2015

In: Research in Astronomy and Astrophysics Vol. 15, No. 8 ( 2015-08), p. 1095-1124

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In: Research in Astronomy and Astrophysics, IOP Publishing, Vol. 15, No. 8 ( 2015-08), p. 1095-1124

Type of Medium: Online Resource

ISSN: 1674-4527

URL: Article

DOI: 10.1088/1674-4527/15/8/002

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2015

detail.hit.zdb_id: 2511247-8

SSG: 6,25

SSG: 16,12

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“Fatty” or “steatotic”: position statement from a linguistic perspective by the Chinese-speaking community

Miao, Lei ; Ye, Shu-Mian ; Zheng, Ming-Hua ; [et al.]

Elsevier BV ; 2024

In: Journal of Hepatology ( 2024-5)

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In: Journal of Hepatology, Elsevier BV, ( 2024-5)

Type of Medium: Online Resource

ISSN: 0168-8278

URL: Article

DOI: 10.1016/j.jhep.2024.05.031

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2027112-8

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Derivation and Validation of a Discharge Disposition Predicting Model after Acute Stroke

Tseng, Hung-Pin ; Lin, Feng-Jenq ; Chen, Pi-Tzu ; [et al.]

Elsevier BV ; 2015

In: Journal of Stroke and Cerebrovascular Diseases Vol. 24, No. 6 ( 2015-06), p. 1179-1186

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In: Journal of Stroke and Cerebrovascular Diseases, Elsevier BV, Vol. 24, No. 6 ( 2015-06), p. 1179-1186

Type of Medium: Online Resource

ISSN: 1052-3057

URL: Article

DOI: 10.1016/j.jstrokecerebrovasdis.2015.01.010

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 2052957-0

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