In:
Angewandte Chemie, Wiley, Vol. 133, No. 20 ( 2021-05-10), p. 11253-11257
Abstract:
The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH 3 ) 2 ) 2 O] 4 {[CeW 5 O 18 ] [TeW 4 O 16 ][CeSn(CH 3 ) 2 ] 4 [TeW 8 O 31 ] 4 } 2 } 46− ( 1 a ) features dimensions of ca. 2.2×2.3×3.4 nm 3 and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v133.20
DOI:
10.1002/ange.202017318
Language:
English
Publisher:
Wiley
Publication Date:
2021
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514305-6
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505872-7
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1479266-7
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506259-7
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