In:
Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-9-24)
Abstract:
Recent evidence suggests that splicing factors (SFs) and alternative splicing (AS) play important roles in cancer progression. We constructed four SF-risk-models using 12 survival-related SFs. In Luminal-A, Luminal-B, Her-2, and Basal-Like BRCA, SF-risk-models for three genes ( PAXBP1 , NKAP , and NCBP2 ), four genes ( RBM15B , PNN , ACIN1 , and SRSF8 ), three genes ( LSM3 , SNRNP200 , and SNU13 ), and three genes ( SRPK3 , PUF60 , and PNN ) were constructed. These models have a promising prognosis-predicting power. The co-expression and protein-protein interaction analysis suggest that the 12 SFs are highly functional-connected. Pathway analysis and gene set enrichment analysis suggests that the functional role of the selected 12 SFs is highly context-dependent among different BRCA subtypes. We further constructed four AS-risk-models with good prognosis predicting ability in four BRCA subtypes by integrating the four SF-risk-models and 21 survival-related AS-events. This study proposed that SFs and ASs were potential multidimensional biomarkers for the diagnosis, prognosis, and treatment of BRCA.
Type of Medium:
Online Resource
ISSN:
1664-8021
DOI:
10.3389/fgene.2021.736423
DOI:
10.3389/fgene.2021.736423.s001
DOI:
10.3389/fgene.2021.736423.s002
DOI:
10.3389/fgene.2021.736423.s003
DOI:
10.3389/fgene.2021.736423.s004
DOI:
10.3389/fgene.2021.736423.s005
DOI:
10.3389/fgene.2021.736423.s006
DOI:
10.3389/fgene.2021.736423.s007
DOI:
10.3389/fgene.2021.736423.s008
DOI:
10.3389/fgene.2021.736423.s009
DOI:
10.3389/fgene.2021.736423.s010
DOI:
10.3389/fgene.2021.736423.s011
DOI:
10.3389/fgene.2021.736423.s012
DOI:
10.3389/fgene.2021.736423.s013
DOI:
10.3389/fgene.2021.736423.s014
DOI:
10.3389/fgene.2021.736423.s015
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2606823-0
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