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A large-scale genome-wide association study meta-analysis of cannabis use disorder

Johnson, Emma C ; Demontis, Ditte ; Thorgeirsson, Thorgeir E ; [et al.]

Elsevier BV ; 2020

In: The Lancet Psychiatry Vol. 7, No. 12 ( 2020-12), p. 1032-1045

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In: The Lancet Psychiatry, Elsevier BV, Vol. 7, No. 12 ( 2020-12), p. 1032-1045

Type of Medium: Online Resource

ISSN: 2215-0366

URL: Article

DOI: 10.1016/S2215-0366(20)30339-4

Language: English

Publisher: Elsevier BV

Publication Date: 2020

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Genome-wide association analysis identifies six new loci associated with forced vital capacity

Loth, Daan W ; Artigas, María Soler ; Gharib, Sina A ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Nature Genetics Vol. 46, No. 7 ( 2014-07), p. 669-677

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 46, No. 7 ( 2014-07), p. 669-677

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3011

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 1494946-5

SSG: 12

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Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Hancock, Dana B. ; Artigas, María Soler ; Gharib, Sina A. ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS Genetics Vol. 8, No. 12 ( 2012-12-20), p. e1003098-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 8, No. 12 ( 2012-12-20), p. e1003098-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1003098

DOI: 10.1371/journal.pgen.1003098.g001

DOI: 10.1371/journal.pgen.1003098.g002

DOI: 10.1371/journal.pgen.1003098.t001

DOI: 10.1371/journal.pgen.1003098.t002

DOI: 10.1371/journal.pgen.1003098.s001

DOI: 10.1371/journal.pgen.1003098.s002

DOI: 10.1371/journal.pgen.1003098.s003

DOI: 10.1371/journal.pgen.1003098.s004

DOI: 10.1371/journal.pgen.1003098.s005

DOI: 10.1371/journal.pgen.1003098.s006

DOI: 10.1371/journal.pgen.1003098.s007

DOI: 10.1371/journal.pgen.1003098.s008

DOI: 10.1371/journal.pgen.1003098.s009

DOI: 10.1371/journal.pgen.1003098.s010

DOI: 10.1371/journal.pgen.1003098.s011

DOI: 10.1371/journal.pgen.1003098.s012

DOI: 10.1371/journal.pgen.1003098.s013

DOI: 10.1371/journal.pgen.1003098.s014

DOI: 10.1371/journal.pgen.1003098.s015

DOI: 10.1371/journal.pgen.1003098.s016

DOI: 10.1371/journal.pgen.1003098.s017

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2186725-2

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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum, Alexander S. ; Colbert, Sarah M. C. ; Johnson, Emma C. ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Mental Health Vol. 1, No. 3 ( 2023-03-22), p. 210-223

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In: Nature Mental Health, Springer Science and Business Media LLC, Vol. 1, No. 3 ( 2023-03-22), p. 210-223

Type of Medium: Online Resource

ISSN: 2731-6076

URL: Article

DOI: 10.1038/s44220-023-00034-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 3123130-5

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Genetic diversity fuels gene discovery for tobacco and alcohol use

Saunders, Gretchen R. B. ; Wang, Xingyan ; Chen, Fang ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Vol. 612, No. 7941 ( 2022-12-22), p. 720-724

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In: Nature, Springer Science and Business Media LLC, Vol. 612, No. 7941 ( 2022-12-22), p. 720-724

Abstract: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury 1–4 . These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries 5 . Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-022-05477-4

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Walters, Raymond K. ; 23andMe Research Team ; Polimanti, Renato ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Nature Neuroscience Vol. 21, No. 12 ( 2018-12), p. 1656-1669

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In: Nature Neuroscience, Springer Science and Business Media LLC, Vol. 21, No. 12 ( 2018-12), p. 1656-1669

Type of Medium: Online Resource

ISSN: 1097-6256 , 1546-1726

URL: Article

DOI: 10.1038/s41593-018-0275-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 1494955-6

SSG: 12

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Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies

Munn‐Chernoff, Melissa A. ; Johnson, Emma C. ; Chou, Yi‐Ling ; [et al.]

Wiley ; 2021

In: Addiction Biology Vol. 26, No. 1 ( 2021-01)

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In: Addiction Biology, Wiley, Vol. 26, No. 1 ( 2021-01)

Abstract: Eating disorders and substance use disorders frequently co‐occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [ r g ], twin‐based = 0.23‐0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome‐wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN] , AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance‐use‐related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism‐based genetic correlations between eating disorder‐ and substance‐use‐related phenotypes. Significant positive genetic associations emerged between AUD and AN ( r g = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN ( r g = 0.23; q 〈 0.0001), and cannabis initiation and AN with binge eating ( r g = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating ( r gs = −0.19 to −0.23; qs 〈 0.04). The genetic correlation between AUD and AN was no longer significant after co‐varying for major depressive disorder loci. The patterns of association between eating disorder‐ and substance‐use‐related phenotypes highlights the potentially complex and substance‐specific relationships among these behaviors.

Type of Medium: Online Resource

ISSN: 1355-6215 , 1369-1600

URL: Issue

URL: Article

DOI: 10.1111/adb.v26.1

DOI: 10.1111/adb.12880

Language: English

Publisher: Wiley

Publication Date: 2021

detail.hit.zdb_id: 1495537-4

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Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

Tang, Wenbo ; Kowgier, Matthew ; Loth, Daan W. ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 7 ( 2014-7-1), p. e100776-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 7 ( 2014-7-1), p. e100776-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0100776

DOI: 10.1371/journal.pone.0100776.g001

DOI: 10.1371/journal.pone.0100776.g002

DOI: 10.1371/journal.pone.0100776.t001

DOI: 10.1371/journal.pone.0100776.t002

DOI: 10.1371/journal.pone.0100776.t003

DOI: 10.1371/journal.pone.0100776.t004

DOI: 10.1371/journal.pone.0100776.s001

DOI: 10.1371/journal.pone.0100776.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Artigas, María Soler ; The International Lung Cancer Consortium ; Loth, Daan W ; [et al.]

Springer Science and Business Media LLC ; 2011

In: Nature Genetics Vol. 43, No. 11 ( 2011-11), p. 1082-1090

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 43, No. 11 ( 2011-11), p. 1082-1090

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.941

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2011

detail.hit.zdb_id: 1494946-5

SSG: 12

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Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

Wilk, Jemma B. ; Shrine, Nick R. G. ; Loehr, Laura R. ; [et al.]

American Thoracic Society ; 2012

In: American Journal of Respiratory and Critical Care Medicine Vol. 186, No. 7 ( 2012-10-01), p. 622-632

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In: American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, Vol. 186, No. 7 ( 2012-10-01), p. 622-632

Type of Medium: Online Resource

ISSN: 1073-449X , 1535-4970

URL: Article

DOI: 10.1164/rccm.201202-0366OC

RVK:

XA 21200

Language: English

Publisher: American Thoracic Society

Publication Date: 2012

detail.hit.zdb_id: 1468352-0

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