In:
American Journal of Reproductive Immunology, Wiley, Vol. 79, No. 1 ( 2018-01)
Abstract:
How is the role of inhibitor of apoptosis proteins ( IAP s) in the development of murine endometriosis lesions? Method of study BALB /c female mice (n = 36) were used for the murine endometriosis model. Endometriotic lesions were surgically induced in mice by transplanting mouse uterine tissue. After 4 weeks of IAP antagonist ( BV 6) treatment, the expression of inflammatory factors in the implants was evaluated using real‐time RT ‐ PCR . Inflammatory state, angiogenic activity, and nuclear factor‐kappa B ( NF ‐κB) activation were assessed by immunohistochemical staining. Results The number, size, and level of inflammatory cytokines (Vegf , Il‐6 , Ccl‐2, Lif ) gene expression in the murine endometriosis‐like lesions were reduced by BV 6 treatment. BV 6 repressed the intensity and rate of positive cells of CD 3, F4/80, and PECAM immunostaining; in addition, the expression of NF ‐κB p65 and phospho‐ NF ‐κB p65 was also attenuated. Conclusion Inhibitor of apoptosis proteins antagonist represses the inflammation status of murine endometriosis‐like lesions via NF ‐κB pathway. IAP s may be a novel therapeutic target for endometriosis.
Type of Medium:
Online Resource
ISSN:
1046-7408
,
1600-0897
DOI:
10.1111/aji.2018.79.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2024667-5
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