In:
British Journal of Pharmacology, Wiley, Vol. 170, No. 4 ( 2013-10), p. 693-695
Abstract:
The award of the 2012 N obel P rize in C hemistry to R obert L efkowitz and B rian K obilka for their work on the structure and function of GPCR s, spanning a period of more than 20 years from the cloning of the human β 2 ‐adrenoceptor to determining the crystal structure of the same protein, has earned both researchers a much deserved place in the pantheon of major scientific discoveries. GPCR s comprise one of the largest families of proteins, controlling many major physiological processes and have been a major focus of the I nternational U nion of B asic and C linical P harmacology C ommittee on R eceptor N omenclature and D rug C lassification ( NC ‐ IUPHAR ) since its inception in 1987. We report here recent efforts by the B ritish P harmacological S ociety and NC ‐ IUPHAR to define the endogenous ligands of ‘orphan’ GPCR s and to place authoritative and accessible information about these crucial therapeutic targets online.
Type of Medium:
Online Resource
ISSN:
0007-1188
,
1476-5381
DOI:
10.1111/bph.2013.170.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2029728-2
SSG:
15,3
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