In:
Journal of Cutaneous Pathology, Wiley, Vol. 41, No. 6 ( 2014-06), p. 494-503
Abstract:
CD20 expression is exceedingly rare in T‐cell lymphomas. Most published cases have been diagnosed as peripheral T‐cell lymphomas, not otherwise specified. Only 18 cases of CD20 ‐positive mycosis fungoides ( MF ) have been previously reported. Here, we describe two cases of CD20 ‐positive MF . Patient 1 was an 84‐year‐old woman who presented with a 5‐year history of multiple pruritic erythematous papules coalescing into thin plaques over 80% of her body surface area. She expired after developing tumors and large cell transformation. Patient 2 was a 67‐year‐old woman with a long‐standing history of tumor stage MF with large cell transformation. She developed a nodular plaque while receiving topical and systemic therapy. In both cases, the neoplastic T‐cells demonstrated a CD4 ‐positive immunophenotype with loss of pan‐T‐cell markers and a monoclonal T‐cell receptor gamma gene rearrangement. CD20 was expressed by a significant population of the neoplastic T‐cells, but these T‐cells lacked expression of other B‐cell markers, including CD79a , CD19 and PAX5 . This report adds to and summarizes the small body of literature describing CD20 ‐positive MF , and discusses diagnostic and clinical implications.
Type of Medium:
Online Resource
ISSN:
0303-6987
,
1600-0560
DOI:
10.1111/cup.2014.41.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2018100-0
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