In:
Journal of Veterinary Emergency and Critical Care, Wiley, Vol. 23, No. 4 ( 2013-07), p. 416-422
Abstract:
To determine the diagnostic ability of blood N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) measurement to differentiate between congestive heart failure (CHF) and noncardiogenic causes for moderate to severe pleural effusion in cats. Design Prospective observational study. Setting University teaching hospital. Animals Twenty‐one cats with moderate to severe pleural effusion. Interventions Venous blood sampling for NT‐proBNP measurement. Measurement and Results According to the results of echocardiographic examination, cats were classified in a group with CHF ( n = 11) or noncongestive heart failure (N‐CHF, n = 10). NT‐proBNP was measured via a feline‐specific test in EDTA plasma with protease inhibitor. NT‐proBNP was significantly ( P 〈 0.0001) higher in the CHF group ( median 982 pmol/L, 355–1,286 pmol/L) than in the N‐CHF group (median 69 pmol/L, 26 – 160 pmol/L) and discriminated exactly (area under the curve = 1.0, 95% confidence interval 1.0–1.0) between both groups. Optimum cut‐off value considering all samples was 258 pmol/L. Conclusion In this small population of cats with pleural effusion, NT‐proBNP was able to differentiate between cats with cardiogenic and noncardiogenic causes of effusion. With the currently recommended method of measurement (ie, EDTA plasma with protease inhibitor), a cut‐off value of 258 pmol/L discriminates effectively between cats with and without CHF.
Type of Medium:
Online Resource
ISSN:
1479-3261
,
1476-4431
DOI:
10.1111/vec.2013.23.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2077212-9
SSG:
22
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