In:
Frontiers in Pediatrics, Frontiers Media SA, Vol. 10 ( 2022-10-17)
Abstract:
Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70–0.99], p = 0.04; replication cohorts: aOR 0.58 [95% CI 0.28–1.22], p = 0.15). While our findings require further replication and investigation of mechanisms of action, they identify a novel target for LRTI prevention and treatment.
Type of Medium:
Online Resource
ISSN:
2296-2360
DOI:
10.3389/fped.2022.979777
DOI:
10.3389/fped.2022.979777.s001
DOI:
10.3389/fped.2022.979777.s002
DOI:
10.3389/fped.2022.979777.s003
DOI:
10.3389/fped.2022.979777.s004
DOI:
10.3389/fped.2022.979777.s005
DOI:
10.3389/fped.2022.979777.s006
DOI:
10.3389/fped.2022.979777.s007
DOI:
10.3389/fped.2022.979777.s008
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2711999-3
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