In:
Hepatology International, Springer Science and Business Media LLC, Vol. 16, No. 4 ( 2022-08), p. 858-867
Abstract:
The optimal locoregional treatment for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) is unclear. This study aimed to investigate the efficacy of Gamma knife radiosurgery (GKR) versus transcatheter arterial chemoembolization (TACE) in HCC patients with PVTT. Methods This retrospective study included 544 HCC patients with PVTT (GKR, 202; TACE, 342). Propensity score matching (PSM) analysis identified 171 matched pairs of patients. The primary endpoint was overall survival (OS). Results Before PSM, the GKR group exhibited longer median OS (mOS) than the TACE group (17.2 vs. 8.0 months, p 〈 0.001). We followed the Cheng’s classification for PVTT. In the subgroup analysis, GKR was associated with significantly longer mOS for patients with PVTT II-IV (17.5 vs. 8.7 months, p 〈 0.001; 17.2 vs. 7.8 months, p = 0.001; 14.5 vs. 6.5 months, p = 0.001, respectively) and comparable OS for patients with PVTT I. After PSM, the GKR group had also a longer mOS than the TACE group (15.8 vs. 10.4 months, p 〈 0.001). In the subgroup analysis, the GKR group demonstrated superior mOS for patients with PVTT II-IV (all p 〈 0.05) and comparable OS for patients with PVTT I. Conclusions GKR was associated better OS than TACE in HCC patients with PVTT, especially for patients with PVTT II-IV. Clinical Trials Registration The study was registered in the Chinese Clinical Trials Registry under the registration number ChiCTR2100051057.
Type of Medium:
Online Resource
ISSN:
1936-0533
,
1936-0541
DOI:
10.1007/s12072-022-10339-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2270316-0
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